Hepatocyte growth factor activator inhibitor

spinqualitylabelsall models Human hepatocyte growth factor activator inhibitor 1 Kunitz domain 1 (green) complex with HGFA (blue) and phosphate (PDB code 1yc0) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Hepatocyte growth factor activator inhibitor (HAI) or Kunitz-type protease inhibitor contains 2 Kunitz domains. HAI-1 is a cell surface-binding protein and regulates hepatocyte growth factor activator activity in the patricellular microenvironment. HAI-1 is the cognate inhibitor of HGFA and matripase. HAI-2 is more efficient inhibitor of pepsin and displays a broader inhibitory spectrum Relevance Abnormal levels of HAI-1 were observed in various types of human cancer. Structural highlights HAI1 is inserted into the binding cleft of HGFA in the manner of other trypsin-like proteases inhibitors.

3D structures of hepatocyte growth factor activator inhibitor

Updated on 29-March-2026

{"openlevels":0}

• Hepatocyte growth factor activator inhibitor 1
  • 1yc0 – hHAI1 Kunitz domain 1 + HGFA – human
    
  • 5ezd – hHAI1 PDK-like and Kunitz domain 1
    
  • 2msx – hHAI1 MANEC-type domain - NMR
    
  • 5h7v – hHAI1 ligand-binding domain
    
  • 4isl, 4isn, 4iso – hHAI1 Kunitz domain 1 + matriptase
    
• Hepatocyte growth factor activator inhibitor 2
  • 4u32 – hHAI2 Kunitz domain 1 + mesotrypsin
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Openfox