Histidine triad nucleotide-binding protein 3D structures

3D structures of histidine triad nucleotide-binding protein

Updated on 26-August-2025

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• HINT1 or adenosine 5’-monophosphoramidase
  • 1kpa, 1kpb, 1kpc, 6g9z, 5o8i, 4zkv, 8wzd – hHINT – human
    
  • 5waa, 5ipb, 7q2u – hHINT (mutant)
    
  • 6rhn – rHINT - rabbit
    
  • 3o1z – rHINT (mutant)
    
  • 6iq1 – HINT – Candida albicans
    
• HINT1 complexes
  • 1av5, 1kpe – hHINT + adenosine derivative
    
  • 1kpf, 3tw2, 6b42, 5klz, 5km0, 5km1, 5km2, 5km3, 5ed3, 6j53, 6j58 – hHINT + nucleotide
    
  • 5ed6, 6j5s, 6j5z, 6j64, 6j65 – hHINT (mutant) + nucleotide
    
  • 5km4, 4zkl, 6n3v, 6n3w, 6n3x, 6n3y, 8p8p, 8pa6, 8pa9, 8paf, 8pai, 9gyp, 9gyq – hHINT + nucleotide derivative
    
  • 5ipd, 5ipe – hHINT + phosphoramidate derivative
    
  • 5kly, 5km6, 5kma, 5ipc – hHINT (mutant) + phosphoramidate derivative
    
  • 4eqe – hHINT + Lys-AMS
    
  • 4eqg – hHINT + Ala-AMS
    
  • 8pwk – hHINT + drug
    
  • 5kmc – hHINT + adenosine-phosphoramidate
    
  • 5wa8, 5wa9 – hHINT (mutant) + Ala-phosphoramidate
    
  • 5kmb – hHINT (mutant) + Trp-phosphoramidate
    
  • 4eqh – hHINT + Trp-AMS
    
  • 5i2e, 5i2f – hHINT + sulfamate inhibitor
    
  • 5emt – hHINT + Cu inhibitor
    
  • 3rhn – rHINT + GMP
    
  • 4rhn, 3qgz – rHINT + adenosine
    
  • 1rzy, 5rhn – rHINT + adenosine derivative
    
  • 3o1c, 3o1x – rHINT (mutant) + adenosine
    
• HINT2
  • 4inc, 6yi0, 6ypr, 6ypx, 6yqd – hHINT
    
  • 5km9 – hHINT + adenosine
    
  • 5km8 – hHINT + cidofovir
    
  • 5km5 – hHINT + triciribine derivative
    
  • 4ini – hHINT + AMP
    
  • 6yqm, 6yvp – hHINT + GMP
    
• HINT
  • 8v1y – HINT + glutamine synthetase – Escherichia coli – Cryo EM
    
• FHIT or Fragile Histidine Triad protein
  • 1fit, 2fit, 4fit – hFHIT
    
  • 3fit – hFHIT + AMP
    
  • 5fit, 6fit – hFHIT + adenosine derivative
    
  • 1fhi – hFHIT + ApppA derivative
    
  • 2fhi – hFHIT (mutant) + ApppA derivative
    

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Michal Harel, Joel L. Sussman