Function
Indole-3-glycerol phosphate synthase or imidazole glycerol phosphate synthase (IGPS) catalyzes the reversible transformation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate (CdRP) to 1-C-(indol-e-yl)-glycerol 3-phosphate (IGP), CO2 and H2O. IGPS is part of the tryptophan biosynthesis[1].
Structural highlights
The active site of IGPS containing the reaction product IGP[2]. Water molecules shown as red spheres.
- ↑ Creighton TE, Yanofsky C. Indole-3-glycerol phosphate synthetase of Escherichia coli, an enzyme of the tryptophan operon. J Biol Chem. 1966 Oct 25;241(20):4616-24. PMID:5332729
- ↑ Hennig M, Darimont BD, Jansonius JN, Kirschner K. The catalytic mechanism of indole-3-glycerol phosphate synthase: crystal structures of complexes of the enzyme from Sulfolobus solfataricus with substrate analogue, substrate, and product. J Mol Biol. 2002 Jun 7;319(3):757-66. PMID:12054868 doi:https://dx.doi.org/10.1016/S0022-2836(02)00378-9
