Kelch-like protein

spinqualitylabelsall models Human Kelch-like protein 1 (Keap1) Kelch domain (cyan) complex with NRF2 Neh2 peptide (green) and sulfate (PDB code 1x2r) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Kelch-like proteins (KLHL) contain multiple Kelch motifs. This motif is about 50 residues long and forms a four-stranded β-sheet blade. Six to eight such blades form a circular β-propeller domain. β-propellers are involved in protein-protein interactions. The N-terminal of KLHL contains other protein domains like BTB (Broad-Tramtrack-Bric-a-brac) which is also involved in protein-protein interactions. KLHL2 KLHL11 is a component of the cullin-RING based E3 ubiquitin-protein ligase system. KLHL3 and KLHL7 KLHL10 are substrate-specific adapters of the cullin-RING based E3 ubiquitin-protein ligase system. KLHL12 may play a role in collagen export. KLHL16 or gigaxonin plays a role in neurofilament architecture. KLHL19 (Keap1) interacts with the Neh2 peptide of NRF2. Disease Somatic mutations in Keap1 were found in lung cancer patients. Relevance NRF2 is a regulator of antioxidant response, hence Keap1 is investigated as a drug target. Structural highlights The interaction of Keap1 with Neh2 is through the first Glu in the latter's ETGE motif. All interactions of Keap1 with Neh2. Water molecules shown as red spheres. 3D Structures of Kelch-like protein Kelch-like protein 3D structures

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