Liver X receptor

spinqualitylabelsall models Human liver X receptorβ ligand binding domain (deepskyblue) complex with retinoic X receptor β (green) and modulator (PDB code 5kya) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Liver X receptors (LXR) are ligand-activated transcription factors of the nuclear receptor family. There are two LXR isoforms α and β which form heterodimers with retinoic X receptor upon activation and bind to the LXR response element found in the promoter region of the target genes. LXR is a lipogenic transcription factor. LXRs modulate the expression of genes in cholesterol and lipid metabolism in response to changes in cellular cholesterol status. Liver X receptor alpha has a role in regulating innate immunity at the genomic level. Liver X receptor beta is an important transcription factor promoting the survival of single-positive thymocytes. See also Intracellular receptors Disease Treatment of mice demonstrating Wilson disease with LXR agonist reduced disease manifestations without worsening neurological symptoms associated with the conventional therapy based on copper chelation. Relevance LXRs have emerged as promising drug targets for anti-atherosclerotic therapies. Structural highlights Human liver X receptor β ligand binding domain complex with retinoic X receptor β and modulator. LXR modulator binds to the LXR in the LXR/retinoic X receptor β heterodimer in a hydrophobic pocket.

3D Structures of liver X receptor

Updated on 10-July-2024

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• Liver X receptor α
  • Intracellular receptors, 5avl, 5hjs, 3ipq, 3ips, 3ipu – hLXR LBD + NCOA-1 peptide + agonist - human
    
  • 1uhl – hLXR LBD + retinoic X receptor β + NCOA-2
    
  • 2acl – mLXR + retinoic X receptor α + agonist – mouse
    
• Liver X receptor β
  • 1upv, 1upw, 5jy3, 3kfc, 4rak, 6s4n, 6s4t, 6s4u, 6s5k – hLXR LBD + agonist
    
  • 6k9g, 6k9h, 6k9m – hLXR LBD (mutant) + agonist
    
  • 1pq6, 1pqc, 1pq9 – hLXR LBD + ligand
    
  • 6jio – hLXR LBD (mutant) + ligand
    
  • 5i4v – hLXR LBD + retinoic X receptor β + agonist
    
  • 5kyj, 5kya – hLXR LBD + retinoic X receptor β + modulator
    
  • 3fal – hLXR LBD + retinoic X receptor β + modulator + retinoic acid
    
  • 5hjp – hLXR LBD + retinoic X receptor β + agonist
    
  • 4nqa – hLXR LBD + retinoic X receptor β + NCOA-2 peptide + DNA
    
  • 4dk7, 4dk8, 5avi – hLXR LBD + NCOA-1 peptide + agonist
    
  • 1p8d – hLXR LBD + NCOA-1 peptide + cholesterol derivative
    
  • 3l0e – hLXR LBD + NCOA-2 peptide + inhibitor
    

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