Liver receptor homolog-1

spinqualitylabelsall models Human LRH-1 (deepskyblue) complex with TIF-2 peptide (green) and an agonist (PDB code 5l11) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Liver receptor homolog-1 (LRH-1) or nuclear receptor subfamily 5 group A member 2 is a nuclear receptor which has critical functions in embryonic development and adult homeoestasis. LRH-1 is a key modulator of female fertility. LRH-1 plays a predominant role in development, reverse cholesterol transport, bile-acid homeostasis and steroidogenesis. See also Intracellular receptors Relevance LRH-1 is implicated in pancreatic, breast and gastrointestinal cancer where it promotes cell proliferation and metastasis. LRH-1 is a potential target for contraception. Structural highlights The ligand of LRH-1 binds deep in the binding pocket and is fully engulfed by it. Agonist binding site.

3D Structures of liver receptor homolog-1

Updated on 27-October-2025

Intracellular receptors – hLRH1 LBD – human
3tx7 – hLRH1 LBD + catenin + phospholipid
4pld – hLRH1 LBD + NCOA-2 peptide + phospholipid
1yok, 1zdu, 4dos, 4ple – hLRH1 LBD + NCOA-2 peptide + phospholipid
5l11, 5syz, 6oqx, 6oqy, 6or1, 6vc2, 6vif, 7jyd, 7jye, 7tt8, 9smq – hLRH1 LBD + NCOA-2 peptide + agonist
8f8m – hLRH1 LBD + NCOA-2 peptide + modulator
1yuc, 4oni – hLRH1 LBD + nuclear receptor 0B2 peptide + phospholipid
1zh7 – hLRH1 LBD + SHP peptide
4dor – hLRH1 LBD + SHP peptide + phospholipid
4rwv – hLRH1 LBD + DAX-1 peptide + phospholipid
5unj – hLRH1 LBD + PGC1A peptide + phospholipid
2a66, 5l0m – hLRH1 DBD 79-187 + DNA
8pki – hLRH1 39-132 + nucleosome – Cryo EM
1pk5 – mLRH1 LBD – mouse
3f5c – mLRH1 LBD (mutant) + DAX-1 peptide

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