Microtubule-associated protein

spinqualitylabelsall models Human microtubule-associated protein light chain 3B (cyan) complex with sequestosome peptide (green) (PDB code 2zjd) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Microtubule-associated protein light chain 3 (LC3) is recruited to autophagosomal membranes during autophagy. The human LC3B is cleaved after synthesis to expose a C-terminal glycine which binds via a phospholipid anchor to autophagosomal vesicle membranes during autophagy. Thus detection of LC3 is a reliable method for monitoring autophagy. The microtubule-associated proteins are classified as 2 types. Type 1 includes MAP1 and type 2 includes MAP2, MAP4 and Tau protein. MAP1 are classical microtubule-associated proteins which bind along microtubule lattice. Tau protein is the principal component of the tangles found in Alzheimer's disease. It is hyperphosphorylated on serines and threonines. Microtubule-associated protein RP/EB family member 1 (MAPRE1) is involved in the regulation of microtubule structure and chromosome stability. It associates with dynactin and the spindle during mitosis. Microtubule-associated protein RP/EB family member 3 (MAPRE3) localizes to the cytoplasmic microtubule network and binds a homolog of the adenomatous polyposis coli tumor suppressor gene. Microtubule-associated protein SPM1 colocalizes to the subpellicular microtubule in the parasite Toxoplasma gondii . Microtubule-associated protein Spiral2 is an Arabidopsis thaliana protein which facilitates the transition of microtubules from pause state to growth. Microtubule-associated protein 1S is related to the MAP1 but is much shorter. MAP1S contains heavy and light chains and is expressed in a wide range of tissues . Disease Microtubule-associated protein Tau is associated with Alzheimer Disease. Tau forms abnormal aggregates in patients' tissues. Mutations in tau protein are associated with neurodegenerative diseases like frontotemporal dementia. Structural highlights LC3 recognizes a sequestosome peptide which is a preferred target for autophagy and binds at the surface of LC3. Water molecules are shown as red spheres. 3D Structures of microtubule-associated protein Microtubule-associated protein 3D structures

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Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman