N-acetylglucosamine-1-phosphate uridyltransferase

spinqualitylabelsall models GlmU complex with its reaction product UDP-GlcNAC, PEG, Mg++, So4, tetraethylene glycol and triethylene glycol (PDB code 2v0j) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function N-acetylglucosamine-1-phosphate uridyltransferase (GlmU) or bifunctional protein GlmU is a bifunctional acetyltransferase/uridyltransferase that catalyzes the formation of UDP-GlcNAc from glucosamine-1-phosphate (G1P)(.) Relevance GlmU is essensial enzyme participating in the biosynthetic pathway for production of peptidoglycans which constitute the mycobacterial cell wall. Hence the inhibition of GlmU is a potential anti-tuberculosis drug target. Structural highlights The UDP-GlcNAc binds to GlmU in the enzyme's N-terminal domain and the majority of the key active site residues are highly conserved across the bacterial GlmU family. The 3D structure of the complex shows an exposed uracil binding pocket, GlcNAc interacting pocket and a lipophilic pocket . Surface representation of the uracil binding pocket.

3D structures of GlmU

Updated on 29-December-2020

{"openlevels":0}

• GlmU
  • 1fxj - EcGlmU - Eschericia coli
    
  • 2v0h - HiGlmU + Co - Haemophilus influenzae
    
  • 1hm0, 1g95 - SpGlmU - Streptococcus pneumoniae
    
  • 5vmk - GlmU - Acinetobacter baumannii
    
  • 3fww - YpGlmU - Yersinia pestis
    
• GlmU complex with product UDP-GlcNAc
  • 2oi7 - EcGlmU + desulfo-CoA + Co + UDP-GlcNAc + GlcNAc-1-phosphate
    
  • 1fwy - EcGlmU + UDP-GlcNac
    
  • 2oi5, 1hv9 - EcGlmU + acetyl-CoA + UDP-GlcNAc
    
  • 2oi6 - EcGlmU + CoA + Co + UDP-GlcNAc + GlcNAc-1-phosphate
    
  • 2v0j - HiGlmU + UDP-GlcNAc
    
  • 1g97 - SpGlmU + UDP-GlcNAc
    
  • 1hm9 - SpGlmU + UDP-GlcNAc + acetyl-CoA
    
  • 6ge9, espt - MtGlmU + acetyl-CoA + UDP-GlcNAc
    
  • 3dj4 - MtGlmU + Co + UDP-GlcNAc
    
  • 4g87, 4g3p, 4g3q - MtGlmU + Co + UDP-GlcNAc + pyrophosphate
    
  • 4g3s - MtGlmU + Co + UDP-GlcNAc + acetylglucosamine-1 phosphate + pyrophosphate
    
  • 3st8 - MtGlmU + G1P + UDP-GlcNac
    
• GlmU other complexes
  • 3twd, 4aa7 - EcGlmU + inhibitor
    
  • 2v0k - HiGlmU + UDP
    
  • 2v0l - HiGlmU + uridine
    
  • 2vd4, 4e1k, 4kn4, 4knx, 4kpx, 4kql, 4kpz, 2w0w, 2w0v - HiGlmU + inhibitor
    
  • 4ac3, 4aaw - SpGlmU + inhibitor
    
  • 1hm8 - SpGlmU + acetyl-CoA
    
  • 2qkx - MtGlmU + acetylglucosamine-1 phosphate
    
  • 4k6r - MtGlmU + ATP + Co + acetylglucosamine-1 phosphate
    
  • 4hcq - MtGlmU + Co + G1P
    
  • 4fce - YpGlmU + G1P
    

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