Neutrotrophin

spinqualitylabelsall models Human neutrotrophin-4 (green) complex with TRKB (pink) and sulfate (PDB code 1hcf) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Neutrotrophins (NT) are released by postsynaptic targets and bind TRK receptors on nerve terminals, The binding activates TRK signaling within distal axons and retrogradely through long axons to distant cell bodies in order to promote gene expression and survival. Thus NTs and other cell-cell signals direct synaptogenesis in the developing brain. Relevance NTs are investigated in studies of diagnosis and therapy of lung diseases. Nts are active in various stem cells and play a role in neurodegenerative diseases like Alzheimer disease and Parkinson Disease.

3D structures of neutrotrophin

Updated on 31-March-2020

• Neutrotrophin-3

1b8k, 1nt3 – hNT3 - human
1bnd – hNT3 + brain derived neutrotrophic factor
3buk – hNT3 + P75NTR

• Neutrotrophin-4

1b98 – hNT4

1b8m – hNT4 + brain derived neutrotrophic factor
1hcf – hNT4 + TRK-B

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel