Poly(A) polymerase 3D structures

3D structures of poly(A) polymerase

Updated on 02-June-2026

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• Poly(A) polymerase
  • 4lt6 – hPAP-Υ – human
    
  • 3pq1 – hPAP
    
  • 1q79, 1f5a - bPAP-α - bovine
    
  • 5a2v - cPAP – chicken
    
  • 2hhp, 2o1p – yPAP - yeast
    
  • 7q73 – fyPAP – fission yeast
    
  • 7q74 – fyPAP (mutant)
    
  • 3aqk, 3aql, 3aqm, 3aqn – PAP residues 18-431 – Escherichia coli
    
  • 3owg – VvPAP catalytic subunit – Vaccinia virus
    
  • 3wfo, 3wfp, 4wby, 4wbz – AaPAP – Aquifex aeolicus
    
  • 4zrl – PAP GLD2+GLD3 – Caenorhabditis elegans
    
• Poly(A) polymerase complex with RNA
  • 3er8, 3er9, 3erc – VvPAP VP55 + RNA
    
  • 1av6 - VvPAP VP39 + SAH + RNA
    
  • 3wfq, 3wfr, 3wfs, 4wc3, 4wc4, 4wc5, 4wc6, 4wc7, 4x0a, 4x0b - AaPAP + RNA
    
  • 4wc2 - AaPAP + RNA + ATP analog
    
• Poly(A) polymerase other complexes
  • 1q78 – bPAP-α + Mg + ATP
    
  • 5a2y, 5a2z, 5a2x, 5a2w - cPAP + nucleotide
    
  • 5a30 - cPAP (mutant) + nucleotide
    
  • 3c66 - yPAP residues 1-526 + Fip1 peptide
    
  • 2q66 – yPAP + polyA + ATP
    
  • 1fa0 - yPAP + Mn + ATP
    
  • 7q72 - fyPAP + Red1
    
  • 2ga9 - VvPAP VP55 + VP39 + ATP
    
  • 2gaf - VvPAP VP55 (mutant) + VP39
    
  • 1jtf, 2vp3 - VvPAP VP39 residues 1-307 (mutant) + M7GPPPG + SAH
    
  • 1b42, 1bky, 1eqa, 3mag, 3mct, 4dcg, 1av6, 1p39, 1v39. 1jsz - VvPAP VP39 residues 1-297 (mutant) + purine derivative + SAH
    
  • 1vp3 - VvPAP VP39 + SAH
    
  • 1vp9, 1eam, 1jte - VvPAP VP39 (mutant) + SAH
    
  • 1vpt - VvPAP VP39 (mutant) + SAM
    
  • 4wc0, 4wc1 - AaPAP + nucleotide
    
  • 9hny - PAP in mitoribosome small subunit – Trypanosoma brucei – Cryo EM
    
• Non-canonical poly(A) polymerase
  • 6w36 – hPAP
    
  • 6w38 – hPAP + Plk4
    
  • 6w3i – hPAP (mutant) + Plk4
    
  • 6w3j – hPAP + Plk4 + Cep192
    
  • 8eqb – hPAP + BRCA2 and CDKN1A- interacting protein + nanobody – Cryo EM
    
• Speckle targeted PIP5K1A-regulated poly(A) polymerase – STAR-PAP
  • 5wu1, 5wu5, 5wu6 – hSTAR-PAP (mutant)
    
  • 5wu2, 5wu3, 5wu4 – hSTAR-PAP (mutant) + UTP
    
  • 8idf – hSTAR-PAP (mutant) + RNA
    
  • 9j8p – hSTAR-PAP + U5 SnRNA – Cryo EM
    

 

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Michal Harel