Polycomb complex proteins 3D structures

3D structures of polycomb complex proteins

Updated on 02-June-2026

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• Polycomb group ring finger protein 1 or Pcgf1
  • 4hpm – hPcgf1 167-255 + BCORL1 - human
    
  • 4hpl – hPcgf1 + BCOR
    
  • 8hcu – hPcgf1 + BCOR + JMJC domain-containing histon demethylation protein
    
  • 5jh5 – hPcgf1 + lysine-specific demethylase + S-phase kinase associated protein 1
    
• BMI-1 or Polycomb group ring finger protein 4 or Pcgf4
  • 5fr6 – hBMI1 residues 121-235
    
  • 2na1 – hBMI1 residues 121-235 /polyhomeotic-like 2– NMR
    
  • 6wi7, 6wi8 – hBMI1 residues 1-104 /RING1B
    
  • 6wi7, 8wi8 – hBMI1 ring domain 1-108/Ring1B
    
  • 7nd1 – hBMI1 ring domain + Ring1B - NMR
    
  • 3rpg – hBMI1 ring domain + Ring1B + Ubch5C
    
  • 9dby, 9dgg – hBMI1 + nucleosome – Cryo EM
    
  • 9dde – hBMI1 + chromatosome – Cryo EM
    
  • 8pp7 – hBMI1 + RING2 + nucleosome – Cryo EM
    
  • 2ckl – mBMI1 ring domain + Ring1B - mouse
    
  • 4r8p – BMI1 ring domain + Ring1B + Ubch5C + DNA - frog
    
• Polycomb group ring finger protein 5 or Pcgf5
  • 4s3o – hPcgf5 ring domain 1-108 + Ring1B + Ubch5C
    
• Polycomb group ring finger protein 6 or Pcgf
  • 2djb – hPcgf6 ring domain - NMR
    
• Polycomb EED
  • 3jpx, 3iiw, 3iiy, 3ij0, 3ij1, 3jzg, 3jzh, 3jzn, 5fr6, 7kxt - hPcG
    
  • 5u69, 5u6d, 5u8a, 5k0m, 5h13, 5u5h, 5u5k, 5u8f, 6sfb, 6sfc, 6w7f, 6w7g, 6yvi, 6yvj, 7msb, 7msd, 7p3c, 7p3g, 7p3j, 7qjg, 7qju, 7qk4, 7si4, 7si5 - hPcG + inhibitor
    
  • 3ijc - hPcG (mutant) + inhibitor
    
  • 6v3x, 6v3y - hPcG + PALI1 peptide
    
  • 3k26, 3k27 - hPcG + histone peptide
    
  • 5wp3 - hPcG + EB22
    
  • 5ttw - hPcG + UNC4859
    
  • 5gsa, 5h14, 5h15, 5h17, 5h19, 5h24, 5h25, 5u5t, 5u62, 5wuk, 6lo2 - hPcG + EZH2 peptide + inhibitor
    
  • 5wg6, 6u4y - hPcG + EZH2
    
  • 7ktp - hPcG + ENX-2 + PcG SUZ12 + RBBP4 - Cryo EM
    
  • 7td5 - hPcG + ENX-2 + PcG SUZ12 + peptide
    
  • 4x3e - hPcG + Jarid2 peptide
    
  • 1pdq, 1pfb - DmPcG chromodomain + histone peptide - Drosophila melanogaster
    
  • 5wf7 - CtPcG + PcG SUZ12 - Chaetomium thermophilum
    
  • 5bjs, 5vk3 - CtPcG + EZH2
    
  • 5wfd - CtPcG + zinc finger containing protein + inhibitor
    
• Polycomb SUZ12
  • 5wak - hPcG + RBBP4
    
  • 5wai - hPcG + RBBP4 + Jarid2 + AEPB2
    
  • 6nq3 - hPcG + RBBP4 + Jumonji + Phd finger protein
    
  • 7at8 - hPcG + EZH2 + nucleosome – Cryo EM
    
  • 2yb8 - DmPcG + CAF1
    
• Polycomb EED+ polycomb EED in polycomb repressive complex 2 PCR2
  • 5w2r, 5ij7, 5ij8, 6b3w – hPCR2 + inhibitor
    
  • 5ls6 – hPCR2 + Jarid2 K116me3
    
  • 5hyn – hPCR2 + Jarid2 K116me3 + histone peptide
    
  • 6c23, 6c24 – hPCR2 + RBBP4 + AEBP2 + Jumonji + SUZ12 + JARID2 - Cryo EM
    
  • 7kso, 8vnz, 9c8u – hPCR2 + RBBP4 + AEBP2 + Jumonji - Cryo EM
    
  • 6wkr – hPCR2 + RBBP4 + AEBP2 + Jumonji + Ub + nucleosome - Cryo EM
    
  • 8t9g – hPCR2 + RBBP4 + AEBP2 + SAH + nucleosome - Cryo EM
    
  • 8tb9 – hPCR2 + RBBP4 + AEBP2 + Jumonji + SAH + nucleosome - Cryo EM
    
  • 8tas – hPCR2 + RBBP4 + AEBP2 + nucleosome - Cryo EM
    
  • 8eqv – hPCR2 + RBBP4 + AEBP2 - Cryo EM
    
  • 7ksr – hPCR2 + RBBP4 - Cryo EM
    
  • 8vmi – hPCR2 + RBPP4 + Jumonji + AEPB2 + histone - Cryo EM
    
  • 8vnv – hPCR2 + RBPP4 + Jumonji + AEPB2 + histone + DNA - Cryo EM
    
  • 8fyh, 9dch – hPCR2 + RBPP4 + Jumonji + AEPB2 + RNA - Cryo EM
    
  • 5wfc – CtPCR2 + histone peptide + inhibitor
    
  • 5tqr – PCR2 + SAM
    
• Polycomb SCMH1
  • 2p0k - hPcG
    
• Polycomb SFMBT
  • 4c5e, 4c5g, 4c5h - DmPcG + PcG PHO
    
  • 5j8y - DmPcG + PcG SCM
    
  • 3h6z - DmPcG + histone peptide
    
• Polycomb PCL
  • 2xk0 - DmPcG tudor domain - NMR
    
  • 5oqd - DmPcG Phd2 and winged-helix domain
    
• Polycomb SCM
  • 2r57 - DmPcG (mutant)
    
  • 2r58, 2r5a - DmPcG (mutant) + methyl-lysine
    
  • 2r5m - DmPcG (mutant) + peptide
    
• Polycomb ASX
  • 8svf – hAsXL1 + BAP1 + nucleosome – Cryo EM
    
  • 9u5u – hAsXL1 + BAP1 + Ub + nucleosome – Cryo EM
    
  • 9atn – hAsXL2 652-670 + histone lysine N-methyltransferase – NMR
    
  • 6cga, 6hgc - DmAsX 207-340 + calypso
    
  • 9v33 - DmAsX 1-340 + calypso + Ub + nucleosome – Cryo EM
    
  • 8h1t – DmAsXL1 + BAP1 + chromatosome – Cryo EM
    
• Polycomb-like protein 1 or PHD finger protein 1 or HPCL1
  • 6wat – hPcL1
    
  • 5xfn, 5xfo – hPcL1 N-terminal 25-340
    
  • 5xfp – hPcL1 N-terminal + DNA
    
  • 5xfq – hPcL1 25-360 + histone 3 + DNA
    
  • 2m0o, 4hcz, 6wau, 6wav – hPcL1 TUDOR domain 28-87 + histone 3.1
    
  • 4bd3 – hPcL3 TUDOR domain + histone 3
    
  • 6nq3 – hPcL3 500-580 + SUZ12 + RBBP4 + Jumonji
    
  • 7lky – hPcL1 TUDOR domain + peptide inhibitor
    
  • 5oqd – DmPcL WINGED-HELIX domain 491-694
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Openfox