Protein kinase C 3D structures

3D structures of protein kinase C

Updated on 03-August-2026

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• Conventional PKCs; Domains – C1 63-169; C2 155-293; kinase 322-673
• PKC-α
  • 2eli – hCPKC-α C1 domain – human – NMR
    
  • 4dnl, 9c5f - hCPKC-α C2 domain
    
  • 3iw4, 4ra4 - hCPKC-α kinase domain + inhibitor
    
  • 8u37 - hCPKC- kinase domain + drug
    
  • 8uak - hCPKC- kinase domain (mutant) + drug
    
  • 1dsy, 3rdj, 3twy, 2nce – rCPKC-α C2 domain – rat
  • 4l1l - rCPKC-α C2 domain + ion
    
  • 5w4s - rCPKC-α C2 domain + peptide
    
  • 3gpe - rCPKC-α C2 domain + Ca + PTDINS
• PKC-β
  • 8se1, 8se2, 8se3, 8se4 – hCPKC-beta
    
  • 2i0e - hCPKC-β II catalytic domain 322-673 + inhibitor
    
  • 9s9t - hCPKC-beta catalytic domain (mutant) + drug
    
  • 1a25 – rCPKC-β C2 domain
    
  • 3pfq - rCPKC-β II (mutant)
    
• PKC-γ
  • 2uzp - hCPKC-γ C2 domain
  • 2e73 - hCPKC-γ C1 domain - NMR
  • 1tbn, 1tbo - rCPKC-γ C2 domain – NMR
    
• Novel PKC
• PKC-δ
  • 1yrk – hNPKC-δ C2 domain + peptide
  • 2yuu - hNPKC-δ C1 domain - NMR
  • 2coa - hNPKC-δ PH domain – NMR
    
  • 1ptq – mNPKC-δ C2 domain – mouse
    
  • 3uej - mNPKC-δ C1B domain
    
  • 3uey, 3uff, 3ugd, 3ugi, 3ugl - mNPKC-δ C1B domain (mutant)
    
  • 6uwa - mNPKC-δ C2+C1B domains
    
  • 9ecs - rNPKC-δ C1B domain + drug
    
  • 1ptr - mNPKC-δ C2 domain + phorbol-acetate
  • 1bdy - rNPKC-δ C2 domain
    
  • 7knd - rNPKC-δ C1B domain
    
  • 7knj, 7ko6, 7l92, 7lcb, 7leo, 7lf3 - rNPKC-δ C1B domain + agonist
    
• PKC-ε
  • 1gmi – rNPKC-ε C2 domain
• PKC-η
  • 2fk9 – hNPKC-η C2 domain
    
  • 3txo, 8fp1, 8fp3 - hNPKC-η kinase domain (mutant) + inhibitor
    
• PKC-θ
  • 4fkd – hNPKC-θ second Cys-rich regulatory domain
    
  • 2enj - hNPKC-θ C2 domain – NMR
  • 2enn, 2enz - hNPKC-θ C1 domain – NMR
  • 1xjd – hNPKC-θ + saurosporine
  • 2jed, 4q9z, 5f9e - hNPKC-θ kinase domain + inhibitor
    
  • 4ra5 - hNPKC-θ kinase domain (mutant) + inhibitor
    
• Atypical PKC
• PKC-ι; domains – PB1 16-99; kinase 249-588
  • 1vd2 – hAPKC-ι PB1 domain – NMR
    
  • 1wmh - hAPKC-ι PB1 domain + PAR6 alpha
    
  • 3a8w, 3a8x, 1zrz - hAPKC-ι kinase domain
    
  • 5li9 - hAPKC-ι kinase domain + ACP
    
  • 6ilz - hAPKC-ι kinase domain + inhibitor
    
  • 3zh8 - hAPKC-ι kinase domain (mutant) + inhibitor
    
  • 1wmh - hAPKC-ι PB1 domain + PAR6 alpha
    
  • 4dc2, 5li1, 8r3x - hAPKC-ι kinase domain + PAR3 peptide
    
  • 8r3y, 9ejk, 9ejl, 9ejm - hAPKC-ι kinase domain + LLGL + par-6 - Cryo EM
    
  • 5lih - hAPKC-ι kinase domain + PKC-εζ peptide
    
• PKC-ν
  • 2d9z – hPKC-ν PH domain - NMR
• PKC-ζ
  • 4mjs - rPKC-ζ + sequestosome-1
    

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Michal Harel