Pyrroline-5-carboxylate dehydrogenase

spinqualitylabelsall models Mouse pyrroline-5-carboxylate dehydrogenase dimer complex with glutarate and PEG400 (PDB entry 4lh3) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Pyrroline-5-carboxylate dehydrogenase or Delta-1-pyrroline-5-carboxylate dehydrogenase(PCD) catalyzes the reversible dehydrogenation of 1-pyrroline-5-carboxylate to glutamate using NAD or NADP as cofactors. PCD participates in glutamate, proline and arginine metabolism. PCD is the second enzyme in proline degradation hence it is important in stress conditions when plants accumulate proline. See also Aldehyde dehydrogenase. Disease Mutation in PCD results in the metabolic disorder type II hyperprolinemia. Structural highlights PCD ligand glutarate binds in the cleft between the catalytic and NAD-binding domains. Water molecules are shown as red spheres. A cystein residue is the nucleophile attacker of the aldehyde.

3D structures of pyrroline-5-carboxylate dehydrogenase

Updated on 23-August-2026

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• Pyrroline-5-carboxylate dehydrogenase
  • Aldehyde dehydrogenase, 4oe5 – hPCD – human
    
  • 3v9h, 3v9i – hPCD (mutant)
    
  • 3v9j, 4lgz, 4e3x – mPCD – mouse
    
  • 4oe6 – yPCD – yeast
    
  • 1uzb - TtPCD –Termus thermophilus
    
  • 4k57 - TtPCD (mutant)
    
  • 3qan – PCD – Bacillus halodurans
    
  • 3rjl - PCD – Bacillus licheniformis
    
  • 4idm – MtPCD – Mycobacterium tuberculosis
    
  • 4ids, 4jdc - MtPCD (mutant)
    
• PCD complex with cofactor
  • 3v9l - mPCD + NAD
    
  • 7mer, 7mes – m1-PCD + NAD + hydroxyl-proline
    
  • 4oe4 - yPCD + NAD
    
  • 2bhp, 2bja – TtPCD + NAD
    
  • 2ehq - TtPCD + NADP
    
  • 2bhq - TtPCD + glutamate + NAD
    
  • 2bjk - TtPCD + citrate + NAD
    
  • 2ehu, 2ejl - TtPCD + serine + NAD
    
  • 2eii - TtPCD + valine + NAD
    
  • 2eit, 2ejd - TtPCD + alanine + NAD
    
  • 2eiw, 2ej6, 2j40 - TtPCD + proline + NAD
    
  • 2j5n - TtPCD + glycine + NAD
    
  • 4ihi - MtPCD + NAD
    
  • 4ns3 - MtPCD (mutant) + cobalamin + NAD
    
• PCD other complexes
  • 8rkr, 8rkq - hPCD + molecular tweezer
    
  • 4lh0 - mPCD + glyoxylate
    
  • 4lh1 - mPCD + malonate
    
  • 4lh2 - mPCD + succinate
    
  • 4lh3 - mPCD + glutarate
    
  • 3v9k - mPCD + proline
  • 4lem - MtPCD (mutant) + cobalamin
    
  • 2iy6 - TtPCD + citrate
    

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Michal Harel, Alexander Berchansky, Joel L. Sussman