The Ramachandran Plot was described on 1963 by Ramachandran, G.N.; Ramakrishnan, C.; Sasisekharan, V. [1]. See Dihedral/Index for explanations. Ramachandran outliers are those amino acids with non-favorable dihedral angles, and the Ramachandran plot is a powerful tool for making those evident. Most of the time, Ramachandran outliers are a consequence of mistakes during the data processing. However, sometimes Ramachandran outliers might play a special role in function. See for example the case of Ser-200 in the structure 1ea5. Let's draw its . The following green links require that you first click the above green link to Ramachandran Plot. Notice that the residues in are colored in yellow, the residues in colored in magenta, in blue and in white. At any time you may residues. Only Gly are allowed in the lower right quarter. If we from the plot, we will find the , with phi/psi angles considered non-favourable for Serine. However, in this case, a Ramachandran-misplaced residue (Ser 200) seems to play an important role in the function of this structure, a member of the alpha/beta hydrolase fold [2].
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This page was last modified 15:24, 15 July 2018.