Function
Ribosomal protein S14 (RPS14) is one of the 21 proteins which belong to the 30S small subunit of the bacterial ribosome or the 30 proteins which belong to the 40S small subunit of the eukaryotic ribosome. It is involved in determining the conformation of 16S RRNA at the A-site[1].
Relevance
RPS14 may negatively regulate p53 citation in acute myeloid leukemia[2].
- ↑ Fewell SW, Woolford JL Jr. Ribosomal protein S14 of Saccharomyces cerevisiae regulates its expression by binding to RPS14B pre-mRNA and to 18S rRNA. Mol Cell Biol. 1999 Jan;19(1):826-34. PMID:9858605
- ↑ Wang L, Luo J, Nian Q, Xiao Q, Yang Z, Liu L. Ribosomal protein S14 silencing inhibits growth of acute myeloid leukemia transformed from myelodysplastic syndromes via activating p53. Hematology. 2014 Jun;19(4):225-31. doi: 10.1179/1607845413Y.0000000127. Epub 2013, Nov 25. PMID:24074450 doi:https://dx.doi.org/10.1179/1607845413Y.0000000127
