Ribosomal protein S6 kinase

spinqualitylabelsall models Human ribosomal protein S6 kinaseα−1 complex with the inhibitor purvalanol (PDB entry 2z7s) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Ribosomal protein S6 kinase (RPS6K) regulates RPS6. RPS6K activity controls the ribosome biogenesis transcriptional program. Ribosomal protein S6 kinase alpha confers resistance towards therapy of acute myeloid leukaemia using venetoclax/azacitidine. Relevance hRPS6K α is overexpressed in breast cancer and is associated with poor prognosis. Inhibitors of RPS6S are studied as potential therapeutic agents for treatment of variety of diseases including diabetes and cancer. Structural highlights The inhibitor purvalanol binds hRPS6K in the ATP-binding pocket between the N- and C-terminal lobes. Active site. Water molecule are shown as red sphere. 3D Structures of Ribosomal protein S6 kinase Ribosomal protein S6 kinase 3D structures

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