Ribosome inactivating protein

spinqualitylabelsall models Ribosome inactivating protein from pokeweed complex with adenine (PDB code 1qci) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Ribosome inactivating protein (RIP) is a bacterial or plant toxin which inhibits protein synthesis. RIP inactivates the ribosomal 60S subunit by N-glycosidic cleavage which results in releasing a specific adenine from 28S rRNA. Type 1 RIP have a single chain, while type 2 RIP (i.e., ricin, ebulin and nigrin) have two chains. Momorcharin is a RIP isolated from several plants. Trichosanthin is a RIP isolated from snake gourd. Relevance RIP is being investigated as an immunotoxin for cancer treatment. Besides the anti-tumor activity of RIP, it was shown to have antiviral, antifungal, insecticidal, ribonuclease and deoxyribonuclease activities. Enhanced expression of RIP in plants confers an increased resistance to virus, fungi, insects, drought and salinity. α-momorcharin has potent inhibitory effect on some cancer cells. Structural highlights The active site of pokeweed RIP contains adenine. Water molecules are shown as red spheres.

3D Structures of ribosome inactivating protein

Ribosome inactivating protein 3D structures

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman