Ryanodine receptor 3D structures

3D Structures of ryanodine receptor

Updated on 14-November-2023

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• Ryanodine receptor 1; Domains – b-trefoil 1-210; SPRY1 650-844; SPRY2 1070-1246; phosphorylation 2733-3050
  • 6w1n – pRyR1 + FKBP1B – pig - Cryo EM
    
  • 6x34 – pRyR1 (mutant) + FKBP1B - Cryo EM
    
  • 8sen, 8seu – rRyR1 - rabbit - Cryo EM
    
  • 8drp – rRyR1 + caffeine + ATP - Cryo EM
    
  • 8sep, 8sew – rRyR1 + ADP - Cryo EM
    
  • 8seo, 8sev – rRyR1 + ATP-g-S - Cryo EM
    
  • 8seq, 8sex – rRyR1 + AMP - Cryo EM
    
  • 8set, 8sf0 – rRyR1 + cAMP - Cryo EM
    
  • 8ses, 8sez – rRyR1 + adenine - Cryo EM
    
  • 8ser, 8sey – rRyR1 + adenosine - Cryo EM
    
  • 8dtb, 8duj, 8dve – rRyR1 + imperacalcin - Cryo EM
    
  • 3hsm, 3ila – rRyR1 b-trefoil domain
    
  • 2xoa – rRyR1 N terminal residues 1-559
    
  • 4i0y, 4i1e, 4i2s, 4i37, 4i3n, 4i6i, 4i8m – rRyR1 N terminal residues 1-559 (mutant)
    
  • 4i7i – rRyR1 N terminal residues 1-536 (mutant)
    
  • 4i96 – rRyR1 N terminal residues 217-536
    
  • 5c33 – rRyR1 SPRY1 domain
    
  • 5c30 – rRyR1 repeat 12 domain residues 857-1054
    
  • 4p9j – rRyR1 SPRY2 domain
    
  • 3rqr – rRyR1 phosphorylation domain + tetrapeptide
    
  • 4ert – rRyR1 phosphorylation domain
    
  • 4esu, 4ett, 4etu – rRyR1 phosphorylation domain (mutant)
    
  • 4uwa, 4uwe, 6fg3, 6foo – rRyR1 – Cryo EM
    
  • 5tb0, 6pv6, 6wot, 6wou, 6wov, 7cf9, 7jmf, 7jmg, 7jmh, 7jmi, 7jmj, 7m6a, 7m6l – rRyR1 + FKBP1B – Cryo EM
    
  • 6m2w – rRyR1 + FKBP1B + calmodulin + caffeine + ATP – Cryo EM
    
  • 3j8h – rRyR1 + FKBP12 – Cryo EM
    
  • 7k0s, 7k0t, 7tdg, 7thj, 7tdi, 7tdj, 7tdk – rRyR1 + AMPPCP – Cryo EM
    
  • 6lqk – RyR1 N terminal residues 1-204 - bee
    
  • 6j6o, 6j6p – dmRyR1 phosphorylation domain (mutant) – diamondback moth
    
  • 6j6l, 6lt9 – dmRyR1 SPRY1 domain (mutant)
    
  • 6kim – dmRyR1 SPRY2 domain (mutant)
    
• Ryanodine receptor 2 (Cardiac Ca+2 release channel); domains - N terminal 1-547; SPRY2 1080-1253; phosphorylation 2699-2904
  • 4jkq – hRyR2 N terminal residues 1-606 - human
    
  • 7kl5 – hRyR2 + calmodulin
    
  • 6jg3 – pRyR2 – Cryo EM
    
  • 6jgz, 6ji0, 6jh6, 6jhn, 6jrr – pRyR2 + FKBP1B - Cryo EM
    
  • 3im5 – mRyR2 b-trefoil domain – mouse
    
  • 3im6, 3im7, 4kei, 4kej, 4kek – mRyR2 b-trefoil domain (mutant)
    
  • 2mc2 – mRyR2 b-trefoil domain - NMR
    
  • 3qr5 – mRyR2 N terminal residues 1-56, 92-217
    
  • 4etv – mRyR2 phosphorylation domain (mutant)
    
  • 6mm6, 6mm7, 6mm8 – mRyR2 phosphorylation domain (mutant) + PKA C-a
    
  • 4l4h – mRyR2 N terminal residues 1-547
    
  • 4l4i – mRyR2 N terminal residues 1-547 (mutant)
    
  • 6j6l – mRyR2 SPRY1 domain (mutant)
    
  • 4p9i – mRyR2 SPRY2 domain
    
  • 4p9l – mRyR2 SPRY2 domain (mutant)
    
  • 6xwv – RyR2 + calmodulin – Drosophila melanogaster
    
• Ryanodine receptor 3
  • 6uha, 6uhb, 6uhe – hRyR3 residues 848-1055
    
  • 6uhh – hRyR3 residues 848-1055 + ATP
    
  • 4erv – hRyR3 residues 2597-2800
    

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Michal Harel