SARS-CoV-2 protein NSP4

spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution. Model Confidence:   Very high (pLDDT > 90)   Confident (90 > pLDDT > 70)   Low (70 > pLDDT > 50)   Very low (pLDDT < 50) AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions below 50 pLDDT may be unstructured in isolation. To the right is an AlphaFold2 3D model of SARS CoV-2 Protein NSP4 (length = 500 amino acids, i.e. YP_009725300.1, color coded by the pLDDT scores. It corresponds to the highest ranked model in terms of the pLDDT confidence scores, i.e., model 1. Morph of the top 5 ranked AlphaFold2 models of SARS-CoV-2 Protein NSP4, rainbow color coded N-C (blue to red). Function Non-structural protein 4 (nsp4) Participates in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication. It helps build fluid-filled bubbles within infected cells. Inside these bubbles, parts for new copies of the virus are constructed. See also Coronavirus_Disease 2019 (COVID-19) SARS-CoV-2_virus_proteins COVID-19 AlphaFold2 Models

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Joel L. Sussman, Jaime Prilusky