SARS-CoV-2 protein ORF3a

spinqualitylabelsall models SARS-CoV-2 ORF3a (PDB entry 6xdc) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Open Reading Frame 3a (ORF3a) Forms homotetrameric potassium sensitive ion channels (viroporin) and may modulate virus release. Up-regulates expression of fibrinogen subunits FGA, FGB and FGG in host lung epithelial cells. Induces apoptosis in cell culture. Downregulates the type 1 interferon receptor by inducing serine phosphorylation within the IFN alpha-receptor subunit 1 (IFNAR1) degradation motif and increasing IFNAR1 ubiquitination. See also Coronavirus_Disease 2019 (COVID-19) SARS-CoV-2_virus_proteins COVID-19 AlphaFold2 Models

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