Sandbox29

1EVE

This sandbox is in use until June 1, 2009 for UMass Chemistry 490a. Others please do not edit this page. Thanks!

Created by Lori Mathis

1eve is a protein that is a drug used to prevent Alzheimer disease. The overall structure of 1EVE contains 2 types of amphipathic elements; 15 beta sheets and 16 alpha helices. 1eve is a fairly standard molecule in the sense that the hydrophic aspects of the protein are well-maintained on the inside, while the hydrophillic portions are around the outside. 1eve has an active name called Acetylcholinesterase, which has a ligand called Aricept. There is an active site in the middle of the molecule. 1eve is considered an AChE inhibitor, in which it has a high affinity for. The overall protein itself was created by a Japanese corporation called the Eisai Company.

spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D load='1eve' size='350' frame='false' scene=
1eve, resolution 2.50Å (default scene)
Ligands:	E20, NAG
Activity:	Acetylcholinesterase, with EC number 3.1.1.7
Structural annotation: Resources: CATH : 1Eve000 InterPro : Ipr000908, Ipr002018, Ipr000997 Pfam : PF00135 SCOP : d1eve__ UniProt : P04058
Functional annotation: Cellular component: synapse cell junction membrane Biological process: neurotransmitter catabolic process acetylcholine catabolic process in synaptic cleft Molecular function: cholinesterase activity hydrolase activity GPI anchor binding acetylcholinesterase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Reference to the Proteopedia pages dedicated to 1EVE, contributors are Eran Hodis, Joel L. Sussman, OCA, Wayne Decatur