Sandbox UC 10

N-TERMINAL ACTIN-BINDING DOMAIN OF HUMAN DYSTROPHIN

spinqualitylabelsall models N-TERMINAL ACTIN-BINDING DOMAIN OF HUMAN DYSTROPHIN (PDB entry 1dxx) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Crystal Structure of Human dystrophin, 1dxx Dystrophin is an essential component of skeletal muscle cells. Its N-terminal domain binds to F-actin and its C terminus binds to the dystrophin-associated glycoprotein (DAG) complex in the membrane.active site CONCLUSIONS: The dystrophin ABD structure reveals a previously uncharacterised arrangement of the CH domains within the ABD. This observation has implications for the mechanism of actin binding by dystrophin and related proteins. Examining the position of three pathogenic missense mutations within the structure suggests that they exert their effects through misfolding of the ABD, rather than through disruption of the binding to F-actin Comparacion de la degeneracion muscular, 1dxx Escenas Zonas conservadas evolutivamente TextToBeDisplayed TextToBeDisplayed

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