Sodium/glucose cotransporter

spinqualitylabelsall models Human glycosylated SGLT2 (cyan) complex with PDZK1-interacting protein (green), drug dapagliflozin and Na+ ion (PDB code 8hez) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Sodium/glucose cotransporter (SGLT) is responsible for glucose absorption across membranes. SGLT1 and SGLT2 which are expressed in different tissues, have similar active sites but differ in their non-active site structures. SGLT1 is responsible of glucose absorption in the small intestine and SGLT2 in kidney. Disease Mutations in SGLT1 cause malabsorption of glucose and galactose. Relevance SGLT2 inhibitors aid in hypertension, acute cardiac failure, bradycardia, acute pulmonary oedema, asthma, bronchitis and COPD. Structural highlights The drug Dapagliflozin contains a glucose moiety which stacks against residue Y290 of SGLT2. The glucose moiety forms multiple H-bonds to SGLT2. Water molecule is shown as red sphere. See also: Canagliflozin Dapagliflozin Empagliflozin 3D structures of sodium/glucose cotransporter Sodium/glucose cotransporter 3D structures

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