Uploads by Rana Saad

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This special page shows all uploaded files.

File list
Date Name Thumbnail Size Description
10:33, 25 July 2015 Summery for the mechanism.jpg (file) 54 KB The agonists and antagonists are anchored in the interdomain crevice of GBR1 by an overlapping set of residues. An antagonist confines GBR1 to the open conformation of the inactive state, while an agonist induces its domain closure for activation
10:20, 25 July 2015 GABAb receptor in the Apo form.jpg (file) 47 KB open conformation at rest
08:36, 25 July 2015 GABAb bound to agonist.jpg (file) 58 KB  
11:09, 10 July 2015 GABAb.bound.to.antagonist.jpg (file) 59 KB GABAb bond to antagonist
06:55, 18 May 2015 Gabab.xu2014.png (file) 50 KB Structure organization of GABAB receptor. GABAB receptor forms heterodimer composed by GABAB1 and GABAB2. GABAB1 is responsible for ligand binding in N-terminal VFT domain, whereas the VFT of GABAB2 fails to bind any known ligand (Xu et al.2014).
06:30, 18 May 2015 GABAb.receptor.cartoon2.png (file) 89 KB A hypothetical model of the human GABAB heterodimer. It was created by me by combining three different structure: extracellular domins, Intracellular and the transmambrane