Speckle-type POZ protein

spinqualitylabelsall models Human SPOP MATH domain (cyan) complex with bromodomain-containing protein 3 (green) (PDB ID [[6i41]). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Speckle-type POZ (pox virus and zinc finger) protein (SPOP) is an adaptor of the cullin-3-based ubiquitin ligase responsible for the degradation of oncoproteins which are overexpressed in many tumor cells. SPOP forms nuclear foci after DNA damage at DNA double-strand break sites. SPOP interacts with bromodomain proteins via their MATH (Meprin And TRAP Homology) domain and regulate them. Disease SPOP mutations contribute to prostate cancer development by altering the steady-state levels of key components in the androgen-signaling pathway . Structural highlights The 3D structure of SPOP MATH domain complex with bromodomain (BRD3) peptide shows the BRD3 located in the shallow groove of the MATH surface with the prostate cancer-associated mutations located at SPOP residues forming H-bonds or hydrophobic contacts with BRD3 and the endometrial-associated (uterus-associated) cancer mutations (in magenta) located far from the BRD3 binding site. 3D structures of speckle-type POZ protein Speckle-type POZ protein 3D structures

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Michal Harel, Alexander Berchansky