Squalene synthase 3D structures

Updated on 29-March-2026

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• Squalene synthase
  • 3vj8, 3vjb – hSQS – human
    
  • 1ezf – hSQS (mutant)
    
  • 4hd1 – SQS – Alicyclobacillus acidocaldarius
    
• Squalene synthase complexes
  • 3lee – hSQS + Mg + bisphosphonate inhibitor
    
  • 3asx, 3q2z, 3q30 – hSQS + Mg + PO4 + inhibitor
    
  • 3vj9, 3vja – hSQS + Ni
    
  • 3vjc – hSQS + Mg + PO4 + zaragozic acid
    
  • 3v66 – hSQS + PO4 + inhibitor
    
  • 3wef – hSQS + FPP analog
    
  • 3weg – hSQS + Mg + FPP analog
    
  • 3weh – hSQS + Mg + presqualene pyrophosphate
    
  • 3wei – hSQS (mutant) + Mn + presqualene pyrophosphate
    
  • 3wej, 3wek – hSQS (mutant) + Mg + presqualene pyrophosphate
    
  • 3wc9 – hSQS (mutant) + farnesyl thiopyrophosphate
    
  • 3wcd – hSQS (mutant) + phenoxy thiocyanate derivative
    
  • 3wcf, 3wch, 3wci, 3wcl – hSQS (mutant) + imidazole phosphonate derivative
    
  • 3wcj – hSQS (mutant) + pyrrolidine derivative
    
  • 3wcm – hSQS (mutant) + pyridine derivative
    
  • 3wsa, 3wsb – hSQS (mutant) + tuberculosis drug
    
  • 3wef, 3weg – hSQS + FPP analog
    
  • 3weh – hSQS + presqualene pyrophosphate
    
  • 3wei, 3wej, 3wek – hSQS (mutant) + presqualene pyrophosphate
    
  • 3wca, 3wcb, 3wcc, 3wce, 3wcg – SQS (mutant) + FPP analog – Trypanosoma cruzi
    
  • 7wgi – AfSQS + PO4 + indole – Aspergillus flavus
    
  • 7wgh – AfSQS (mutant) + POP + PO4 +farnesyl thiopyrophosphate
    
• Dehydrosqualene synthase (DSQS)
  • 3vjd, 2zco – SaDSQS – Staphylococcus aureus
    
  • 3nri – SaDSQS + dehydrosqualene
    
  • 3npr, 3adz – SaSQS + presqualene pyrophosphate
    
  • 3lgz – SaSQS (mutant) + presqualene pyrophosphate
    
  • 3vje – SaDSQS (mutant) + zaragozic acid
    
  • 3ae0 – SaDSQS + geranylgeranyl + thiopyrophosphate
    
  • 3w7f, 5yis – SaDSQS + farnesyl + thiopyrophosphate
    
  • 3acw, 3acx, 3acy, 3tfv, 3tfn, 3tfp, 4f6v, 4f6x, 2zcs, 2zcq, 2zy1, 2zcr, 4e9z, 4e9u, 4ea0, 4ea1, 4ea2 – SaDSQS + inhibitor
    

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Michal Harel, Openfox