Succinate-semialdehyde dehydrogenase

spinqualitylabelsall models Structure of succinate-semialdehyde dehydrogenase complex with NADPH and succinate semialdehyde (PDB code 3vz3). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Succinate-semialdehyde dehydrogenase or α-ketoglutaric semialdehyde dehydrogenase or succinyl-CoA reductase (SSD) catalyzes the conversion of succinate semialdehyde, NAD+ and water to succinate, NADH and H+. SSD participates in glutamate and butyrate metabolism. See also Aldehyde dehydrogenase. Disease SSD deficiency is a disorder of GABA metabolism with symptoms of seizures, delayed development and hypotonia. Structural highlights The active site of SSD contains the substrate succinate semialdehyde and the cofactor NADP. Water molecules are shown as red spheres. Whole binding site.

3D structures of succinate-semialdehyde dehydrogenase

Updated on 06-December-2023

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• Succinate-semialdehyde dehydrogenase
  • Aldehyde dehydrogenase, 2w8o – hSSD - human
    
  • 2w8p – hSSD (mutant)
    
  • 4it9, 3vz1 – SySSD - Synechococcus
    
  • 3vz2 – SySSD (mutant)
    
  • 4v6h – SSD – Burkholderia pseudomallei
    
  • 5vbf – SSD – Burkholderia vietnamiensis
    
  • 3rh9 – SSD – Marinobacter aquaeolei
    
  • 4ogd – SpSSD – Streptococcus pyogenes
    
  • 5x5t – AbSSD – Azuspirillum brasilense
    
• Succinate-semialdehyde dehydrogenase complexes
  • 2w8q – hSSD (mutant) + succinate
    
  • 2w8r – hSSD (mutant) + ADP
    
  • 4ita – SySSD + NADPH
    
  • 4itb – SySSD + NADPH + succinic semialdehyde
    
  • 3vz3 – SySSD (mutant) + NADPH + succinic semialdehyde
    
  • 3jz4 – SSD + NADPH – Escherichia coli
    
  • 4oht – SpSSD + NADPH
    
  • 4ywu, 4ywv – SySSD + oxobutanoic acid + succinic semialdehyde
    
  • 5x5u – AbSSD + NAD
    
  • 8c54 – SSD + NADH – Rhizobium leguminosarum – Cryo EM
    
  • 8cej – CkSSD + mesaconyl-c1-CoA – Clostridium kluyveri
    
  • 8cek – CkSSD + NADPH
    

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