Synaptosomal-associated protein

spinqualitylabelsall models RAT neuronal SNARE complex containing SNAP25 N-terminal SNARE motif (gold), SNAP25 C-terminal SNARE motif (red), syntaxin-1a SNARE motif (cyan), VAMP2 SNARE motif (magenta), glycylglycylglycine and sulfate (PDB code 3hd7) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Synaptosomal-associated protein (SNAP) and in particular SNAP25 is localized on the synapse and participates in exocytosis and neurotransmitter release. SNAP25, Syntaxin 1a and VAMP (Vesicle-associated membrane protein) form the stable soluble SNARE complex and their interaction is involved in the release of synaptic vesicles. Disease Mutation in SNAP25 induces a severe working memory deficit and some common adulthood psychiatric disorders. Relevance Decreased expression of SNAP25 is associated with Alzheimer's disease, Down syndrome and ADHD disorder. Structural highlights SNAP25 has two SNARE motifs - one at its N-terminal and the other at its C-terminal. These motives make complexes with Syntaxin and VAMP2.

3D structures of synaptosomal-associated protein

Updated on 29-November-2018

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• SNAP23
  • Syntaxin – hSNAP23 N-terminal coiled-coil – human
    
• SNAP25; N-terminal SNARE motif 1-82; C-terminal SNARE motif 141-203;
  • Vesicle-associated membrane protein, Syntaxin – rSNAP25 + vesicle fusing ATPase – rat – cryo EM
    
  • 3j96, 3j97, 3j98, 3j99, 6mdm, 6mdn – rSNAP25 + vesicle fusing ATPase + VAMP2 + rSyntaxin 1a SNARE motif + α-soluble NSF attachment protein – cryo EM
    
  • 1xtg – hSNAP25 C-terminal SNARE motif – human
    
  • 3dda, 3ddb – hSNAP25 C-terminal SNARE motif + botulinum neurotoxin
    
  • 1jth – rSNAP25 N-terminal SNARE motif + rSyntaxin 1a SNARE motif
    
  • 1kil – hSNAP25 N-terminal SNARE motif + hSNAP25 C-terminal SNARE motif + complexin-1 + VAMP2 + rSyntaxin 1a SNARE motif
    
  • 5w5c, 5w5d – rSNAP25 N-terminal SNARE motif + rSNAP25 C-terminal SNARE motif + rSyntaxin 1a SNARE motif + VAMP2 + synaptotagmin + complexin-1
    
  • 5lob, 5low – rSNAP25 N-terminal SNARE motif + rSNAP25 C-terminal SNARE motif + rabphilin 3A
    
  • 3hd7, 3ipd, 3rk2, 3rl0 – rSNAP25 N-terminal SNARE motif + rSNAP25 C-terminal SNARE motif + VAMP2 + rSyntaxin 1a SNARE motif
    
  • 5ccg, 5cch, 5cci – rSNAP25 N-terminal SNARE motif + rSNAP25 C-terminal SNARE motif + rSyntaxin 1a SNARE motif + synaptotagmin + VAMP2
    
  • 5kj7, 5kj8 – rSNAP25 N-terminal SNARE motif + rSNAP25 C-terminal SNARE motif + rSyntaxin 1a SNARE motif + synaptotagmin + VAMP3
    
  • 2n1t – hSNAP25 N-terminal SNARE motif + hSNAP25 C-terminal SNARE motif + rSyntaxin 1a SNARE motif + synaptotagmin + VAMP2 - NMR
    
  • 1urq – rSNAP25 N-terminal SNARE motif + rSNAP25 C-terminal SNARE motif + tomosyn + rSyntaxin 1a SNARE motif
    
• SNAP29
  • 4wy4 – hSNAP29 N-terminal SNARE motif + hSNAP29 C-terminal SNARE motif + VAMP8 + rSyntaxin 17 SNARE motif
    

Updated on 29-November-2018 {{#tree:id=OrganizedByTopic|openlevels=0|

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel