Synaptotagmin 3D structures

Updated on 11-December-2023

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• Synaptotagmin-1; domains: toxin-binding 33-53; C2A 141-268; C2B 267-446
  • 3f00, 3f01, 3f04, 3f05 – hSYT1 C2A domain – human
    
  • 2k45 – hSYT1 C2A domain - NMR
    
  • 7u4q – hSYT1 C2A domain (mutant)
    
  • 6tz3 – hSYT1 C2B domain
    
  • 6u41, 6u4u, 6u4w, 7tua, 7tx9 – hSYT1 C2B domain (mutant)
    
  • 2r83 – hSYT1 C2A+C2B domains
    
  • 5t0r, 5vfe – mSYT1 C2A domain – mouse
    
  • 5vff, 5vfg, 5t0s – mSYT1 C2B domain
    
  • 1rsy, 4wee, 6cxw – rSYT1 C2A domain – rat
    
  • 1k5w, 1byn – rSYT1 C2A domain - NMR
    
  • 1tjx, 1tjm, 1uov, 1uow – rSYT1 C2B domain
    
  • 5ccj – rSYT1 C2B domain (mutant)
    
  • 8faf – oSYT1 C2A domain - octopus
    
  • 8fam – oSYT1 C2A domain (mutant)
    
  • 7as6, 7atp – SYT1 C2A domain - Arabidopsis thaliana
    
  • 7a1r – SYT1 C2A domain – Trypanosoma brucei
    
• Synaptotagmin-1 complex
  • 2lha – hSYT1 C2B domain + inositol hexaphosphate - NMR
    
  • 4v11 – hSYT1 C2B domain + synaptic vesicle glycoprotein peptide
    
  • 2k4a – hSYT1 C2A domain + heparin-binding growth factor - NMR
    
  • 2ki6 – hSYT1 C2A domain + heparin-binding growth factor + protein S100 A13
    
  • 4isq, 6g5f, 6g5k, 6qns – hSYT1 toxin-binding domain + botulinum neurotoxin B2-binding domain
    
  • 6zvn – hSYT1 C2B domain + botulinum neurotoxin B2-binding domain
    
  • 2n1t – hSYT1 C2B domain + VAMP-2 + syntaxin-1A + SNAP-25
    
  • 8c5h – rSYT1 C2A domain + nanobody
    
  • 2yoa – rSYT1 C2B domain + phosphoserine
    
  • 5w5d, 5w5c – rSYT1 C2B domain + VAMP-2 + syntaxin-1A + SNAP-25 + complexin-1
    
  • 5cch, 5ccg, 5kj7, 5cci, 5kj8 – rSYT1 C2A+C2B domains + VAMP-2 + syntaxin-1A + SNAP-25
    
  • 6mti – rSYT1 C2A+C2B domains + VAMP-2 + syntaxin-1A + SNAP-25 – Cryo EM
    
• Synaptotagmin-2
  • 4npk, 4npj – hSYT2 C2A+C2B domains 363-662
    
  • 4p42 – hSYT2 SMP+C2A+C2B domains 191-662
    
  • 6g5g – hSYT2 toxin-binding domain + botulinum neurotoxin B2-binding domain
    
  • 2np0, 4kbb – mSYT2 ectodomain 1-60 + botulinum neurotoxin B
    
  • 4isr – rSYT2 toxin-binding domain + botulinum neurotoxin DC heavy chain
    
  • 2nm1 – rSYT2 toxin-binding domain + botulinum neurotoxin B receptor-binding domain
    
• Synaptotagmin-3
  • 3hn8 – rSYT3 C2A+C2B domains 293-588
    
  • 1dqv – rSYT3 C2A+C2B domains - NMR
    
• Synaptotagmin-4
  • 1ugk – hSYT4 C2A domain - NMR
    
  • 1w15, 1w16 – rSYT4 C2B domain
    
• Synaptotagmin-5
  • 5h4y – hSYT5 C2A domain
    
  • 5h4z – hSYT5 C2A domain (mutant)
    
• Synaptotagmin-7
  • 2d8k – hSYT7 C2A domain - NMR
    
  • 6anj – rSYT7 C2A domain
    
  • 6ank – rSYT7 C2A+C2B domains
    
  • 3n5a – mSYT7 C2B domain 266-403
    
• Synaptotagmin-13
  • 1wfm – hSYT13 C2A domain - NMR
    
• Synaptotagmin-like protein 2
  • 3bc1 – hSYTL2 Rab-binding domain
    
  • 7opp, 7opq, 7opr – hSYTL2 + Rab 27A
    
• Synaptotagmin-like protein 4
  • 5x6t – hSYTL4 N-terminal Zn finger - NMR
    
  • 2csz – hSYTL4 RING domain - NMR
    
  • 3fdw – hSYTL4 C2 domain
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman