Tdp-43

TDP-43 helical stabilizers

spinqualitylabelsall models Compound A is the best current binder to the healthy helical tdp-43 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037571/) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D This is the healthy helical coil (residues 307-349) of TDP-43. A key biomolecular cause of ALS appears to be a helix-sheet transition in this area, leading to the formation of protein fibrils. Function Tdp-43 or TAR DNA-binding protein 43 is a heterogeneous nuclear ribonucleoprotein which has crucial roles in gene expression and alternative splicing, stress response, neuronal functions such as neurite outgrowth and many other cellular processes. Disease Tdp-43 mutations were found ion familial and sporadic ALS patients. Phosphorylated Tdp-43 is deposited as cytoplasmic and intranuclear inclusions in brains of patients with frontotemporal lobar degeneration and ALS. Structural highlights This is a sample scene created with SAT to color by Group, and another to make a transparent representation of the protein.

3D Structures of Tdp-43

Updated on 17-March-2018

2cqg – hTDP-43 RRM1 domain – human - NMR
1wf0 – hTDP-43 RRM2 domain - NMR
5mrg, 2n4p, 5x4f – hTDP-43 N-terminal domain - NMR
5mdi – hTDP-43 N-terminal domain
2n2c, 2n3x – hTDP-43 prion-like helix - NMR
2n4g, 2n4h – hTDP-43 prion-like helix (mutant) - NMR
4y0f, 4iuf – hTDP-43 RRM1 domain + DNA
4y00 – hTDP-43 RRM1 domain (mutant) + DNA
4bs2 – hTDP-43 RRM1+RRM2 domains + RNA - NMR
3d2w – TDP-43 RRM2 domain + DNA - mouse

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Gerry Lushington, Michal Harel