Template:ABSTRACT PUBMED 24155387
The Nipah virus phosphoprotein, P, is multimeric and tethers the viral polymerase to the nucleocapsid. We present the crystal structure of the multimerization domain of Nipah P: a long, parallel, tetrameric, coiled coil with a small, alpha-helical cap structure. Across the paramyxoviruses, these domains share little sequence identity; yet retain similar length and structural organization, suggesting a common requirement for scaffolding or spatial organization of the functions of P in the virus life cycle.
Crystal structure of the Nipah virus phosphoprotein tetramerization domain., Bruhn-Johannsen JF, Barnett K, Bibby J, Thomas J, Keegan R, Rigden D, Bornholdt ZA, Saphire EO, J Virol. 2013 Oct 23. PMID:24155387
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
