Toll-like Receptor 3D structures

3D Structures of Toll-like Receptors

Updated on 29-March-2026 - For a general description of the protein see Toll-like Receptors

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• Toll-like receptor 1; Domains – Transmembrane+juxtamembrane 581-629; TIR 625-785; ligand-binding (LBD) 22-703; transmembrane 698-730
  • 1fyv – hTLR1 TIR domain – human
    
  • 6nih - hTLR1/VLRB.61
    
  • 2z7x, 2z81, 2z82 – hTLR1/VLRB.61 + hTLR2/VLRB.61 + lipopeptide
• Toll-like receptor 2
  • 8ar0, 8ar1, 8ar2, 8ar3 – hTLR2 transmembrane+juxtamembrane domain – NMR
    
  • 1fyw, 7nux, 7nux – hTLR2 TIR domain
    
  • 7nt7 – hTLR1 TIR domain – NMR
    
  • 1fyx, 1o77 - hTLR2 TIR domain (mutant)
    
  • 2z80 – hTLR2/VLRB.61
    
  • 3a79 – hTLR2/VLRB.61 + hTLR6/VLRB.61 + lipopeptide
    
  • 6nig – hTLR2/VLRB.61 + diprovocim
    
  • 3a7b - mTLR2/VLRB.61 – mouse
    
  • 3a7c - mTLR2/VLRB.61 + PE-DTPA
    
  • 5d3i – mTLR2 + SSL3
    
• Toll-like receptor 3
  • 1ziw, 2a0z – hTLR3 LBD
    
  • 5gs0 – hTLR3 ectodomain + antibody
    
  • 2mk9, 2mka – hTLR3 transmembrane domain - NMR
    
  • 3ulv, 3ulu, 5gs0 – hTLR3 LBD + antibody
    
  • 7c76 – hTLR3 + UNC93B1 – Cryo EM
    
  • 7wm4, 7wv3, 7wv4, 7wv5, 7wvj – hTLR3 LBD + RNA – Cryo EM
    
  • 7wve – hTLR3 LBD (mutant) + RNA – Cryo EM
    
  • 7wvf – hTLR3 LBD + antibody + RNA – Cryo EM
    
  • 7c77 – mTLR3 + UNC93B1 – Cryo EM
    
  • 7da7, 7das – mTLR3 LBD + RNA – Cryo EM
    
  • 3cig – mTLR3 LBD
    
  • 3ciy - mTLR3 LBD + RNA
    
• Toll-like receptor 4
  • 2z62, 2z63, 2z66, 3ul9 – hTLR4/VLRB.61
    
  • 3ul8, 3ul7 – hTLR4/VLRB.61 (mutant)
    
  • 5nam, 5nao – hTLR4 transmembrane domain - NMR
    
  • 3fxi, 4g8a - hTLR4 LBD + lymphocyte antigen 96
    
  • 3ula - hTLR4/VLRB.61 + lymphocyte antigen 96
    
  • 2z64, 2z65, 5ijc, 5ijd, 3vq1, 3vq2 – mTLR4 LBD + lymphocyte antigen 96
    
  • 7mlm - mTLR4/VLRB.61 + lymphocyte antigen 96 + sulfatide
    
• Toll-like receptor 5
  • 3j0a – hTLR5
    
• Toll-like receptor 5A
  • 7b1b, 7b1c, 7b1d – TLR5A + Spz1C – yellow fever mosquito - Cryo EM
    
• Toll-like receptor 5B
  • 5gy2 – zfTLR5B N-terminal + flagellin - zebrafish
    
  • 6bxa – zfTLR5B N-terminal + VLR2
    
  • 6bxc – zfTLR5B N-terminal + VLR9
    
  • 3v44, 6bxa, 6bxc – zfTLR5B/VLRB.61
    
  • 3v47 – zfTLR5B/VLRB.61 + flagellin
    
• Toll-like receptor 6
  • 4om7 – hTLR6 TIR domain
    
• Toll-like receptor 7
  • 7cyn – hTLR7 + UNC93B1 – Cryo EM
    
  • 5gmf – moTLR7 + guanosine + poly-U - monkey
    
  • 5gmg – moTLR7 + loxoribine + poly-U
    
  • 5gmh – moTLR7 + resiquimod + poly-U
    
  • 5zsl, 5zsm, 5zsn – moTLR7 (mutant) + RNA
    
  • 5zsg, 5zsh, 5zsi, 5zsj, 6lvz, 6lw1, 7ytp – moTLR7 (mutant) + inhibitor
    
  • 6lvx, 6lvy, 6lw0 – moTLR7 (mutant) + antagonist
    
  • 6if5 – moTLR7 (mutant) + cGMP
    
  • 5zsf – moTLR7 (mutant) + drug
    
  • 5zsa, 5zsb, 5zsd, 5zse – moTLR7 (mutant) + RNA + inhibitort
    
• Toll-like receptor 8
  • 3w3g, 5hdh – hTLR8
    
  • 3w3j, 3w3k, 3w3l, 3w3m, 3w3n, 3wn4, 5awa, 5awc, 5awb, 5awd, 4r6a, 4qbz, 4qc0, 5az5, 6v9u, 6wml, 6zjz, 7crf, 7r52, 7r53, 7r54 – hTLR8 + agonist
    
  • 6kya, 6ty5, 7rc9, 7ytx, 8pfi – hTLR8 + antagonist
    
  • 4r07, 4r09 – hTLR8 + ORN06
    
  • 4r08 – hTLR8 + RNA
    
  • 4r0a – hTLR8 + uridine
    
  • 5z14, 5z15, 5wyx, 5wyz – hTLR8 + inhibitor
    
• Toll-like receptor 9
  • 3wpb – hoTLR9 - horse
    
  • 3wpc, 3wpd, 3wpe, 5y3j, 5y3k, 5y3l, 5y3m – hoTLR9 + DNA
    
  • 3wpf – mTLR9
    
  • 3wpg, 3wph, 3wpi – mTLR9 + DNA
    
  • 5zln – mTLR9 (mutant) + DNA
    
  • 4qdh – mTLR9/VLRB.61
    
• Toll-like receptor 10
  • 2j67 – hTLR10 TIR domain
• Toll-like receptor 13
  • 4z0c – mTLR13 + RNA
    
• Toll-like receptor 15
  • 7ylf, 7ylg – TLR10 TIR domain - chicken
    

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