Transcription initiation factors 3D structures

3D structures of transcription initiation factors

Updated on 29-March-2026 - For a general description of the protein see Transcription initiation factor

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• TFIIA
  • 5m4s – hTFIIA – human
  • 1nvp – hTFIIA + TBP + DNA
  • 6mzm – hTFIIA+TFIID + TBP + DNA – Cryo EM
  • 1nh2, 1rm1, 1ytf – yTFIIA + TBP + DNA – yeast
  • 7oh9, 7oha – yTFIIA in nucleosome complex - CryoEM
  • 5fur – yTFIIA + yTFIIF + TBP + DNA - CryoEM
• TFIIB
  • 1tfb – hTFIIB – NMR
  • 1dl6 - hTFIIB N terminal – NMR
  • 5wh1 - hTFIIB C terminal
  • 1rly - hTFIIB Zn ribbon domain + Zn – NMR
  • 1ro4 - hTFIIB Zn ribbon domain – NMR
  • 1c9b, 1vol  – hTFIIB + TBP + DNA
  • 1ais, 1d3u - TFIIB C terminal + TBP + DNA – Pyrococcus woesei
  • 1pft – PfTFIIB N terminal – Pyrococcus furiosus – NMR
  • 5o9i, 5o9j - TFIIB – Methanocaldococcus jannaschii
• TFIIA+TFIIB
  • 6o9l – hTFIIA+TFIIB in RNA polymerase II – Cryo EM
  • 7zwc – hTFIIA+TFIIB + SNAPc:TBP – Cryo EM
• TFIIIB
  • 5n9g – hTFIIIB + TBP + DNA
  • 6f40, 6f41, 6f42, 6f44, 6cnb, 6cnc, 6cnd, 6cnf, 6eu0 – yTFIIIB + RNA polymerase III – Cryo EM
  • 7q5b – yTFIIIB in TY3 retrotransposon complex – Cryo EM
• TFIID
  • 1bh8 – hTFIID
  • 1eqf, 7k3o – hTFIID subunit 1
  • 6fic, 7jjg, 7jjh, 7jsp, 7jtc, 7k03, 7k0d, 7k0u, 7k1p, 7k27, 7k42, 7k6f, 7l6x, 7lb0, 7lb1, 7lb2, 7lb3, 7n42, 7p4s, 7t2i, 7t36 – hTFIID subunit 1 + inhibitor
  • 3uv5 – hTFIID subunit 1 bromodomain 1-2
  • 3uv4 – hTFIID subunit 1 bromodomain 2 1501-1635
  • 5mg2, 6bqd, 6p38, 6p39, 6p3a – hTFIID subunit 1 bromodomain 2 + inhibitor
  • 3aad – hTFIID subunit 1 bromodomain 1-2 + histone chaperone ASF1A
  • 4yym, 4yyn – hTFIID subunit 1 bromodomain 2 + histone peptide
  • 5i1q, 5i29 – hTFIID subunit 1 bromodomain 2 + pyrrolopyridone
  • 5c13, 5wxg, 5wxh, 5xmy – hTFIID subunit 3 PHD finger 853-915 + histone peptide
  • 5eg2 - hTFIID subunit 10 + SETD7 + SAH
  • 4wv4 - hTFIID subunits 8+10
  • 4grw - hTFIID subunits 1+7
  • 6f3t - hTFIID subunits 5+6+9
  • 6mzl, 7eg9, 7egb, 7egc, 7ege, 7ena, 7enc - hTFIID subunits 1-13 + TBP – Cryo EM
  • 6mzd, 7egf - hTFIID subunits 1,3-6,9-13 + TBP – Cryo EM
  • 6mzc, 7egg - hTFIID subunits 2,4-6,8-12 – Cryo EM
  • 7egh - hTFIID subunits 1,2,6-8 + DNA – Cryo EM
  • 7ktr, 7kts, 8h7g - hTFIID in SAGA coactivator complex – Cryo EM
  • 1bh9 – hTFIID + PCMBS
  • 6df4, 6df7 – TFIID subunit 1 bromodomain 2 + inhibitor - rabbit
  • 1tba – TFIID – Drosophila melanogaster - NMR
  • 1qn3, 1qn4, 1qn5, 1qn6, 1qn7, 1qn8, 1qn9, 1qna, 1qnb, 1qnc, 1qne – AtTFIID + DNA
    Arabidopsis thaliana
  • 7ac1 - AtTFIID subunit 4 RST domain - NMR
  • 4oy2 - yTFIID subunits 1+7
  • 6mip - yTFIID subunit 14
  • 6lqz - yTFIID subunit 14 + STH1EBMC - NMR
  • 5d7e, 5iok, 6min, 6mio, 6miq, 7f4a – yTFIID subunit 14 YEATS domain 1-137 + histone peptide
  • 7uhe – yTFIID subunit 14 ET domain 168-243 + C-terminal domain 1392-1403
  • 6t9j - yTFIID subunit 12 + Spt20 + transcription-associated protein – Cryo EM
  • 6t9i, 6t9k - yTFIID in SAGA complex – Cryo EM
  • 6hqa, 6tb4, 6tbm - TFIID in SAGA complex – Komagataella phaffii – Cryo EM
• TFIID+TFIIA
  • 7egd, 7egi, 7egj – hTFIID+TFIIA + TBP + DNA – Cryo EM
• TFIIE
  • 7nvw, 7nvx – hTFIIE + TFIIH + Mat1 + DNA – Cryo EM
  • 5gpy - hTFIIE subunit 1 1-217 + subunit 2 141-217
  • 1vd4 - hTFIIE Zn finger domain 113-174 – NMR
  • 2rnq – hTFIIE C terminal 378-439 - NMR
  • 2rnr – hTFIIE C terminal + TFIIH PH domain- NMR
  • 6pin, 6xjf – PfTFIIE-a
• TFIIF
  • 1f3u – hTFIIF
  • 1nha – hTFIIF C terminal - NMR
  • 1i27 – hTFIIF C terminal (mutant)
  • 1j2x – hTFIIF C terminal + RNA polymerase CTD phosphatase peptide
  • 1onv – hTFIIF C terminal + serine phosphatase peptide - NMR
  • 2k7l – hTFIIF C terminal + FCP1 peptide - NMR
  • 7mei, 7mk9 – yTFIIH in trailing EC complex – Cryo EM
• TFIIH
  • 5ivw, 6o9m, 7o4k, 7o4l – hTFIIH in preinitiation complex – Cryo EM
• TF in RNA polymerase II
  • 5iy6, 5iy7, 5iy8, 5iy9, 5iya, 5iyb, 5iyc, 5iyd – hTFIIA + hTFIIB + hTFIIE + hTFIIF + hTFIIH + DNA – Cryo EM
  • 7edx, 7eg7, 7eg8, 7eg9, 7ega, 7nvv, 7nvy, 7nvz, 7nw0 – hTFII in RNA polymerase – Cryo EM
  • 8wb0 – hTFIIF + in RNA polymerase II transcription pre-initiation complex - CryoEM
  • 8iue, 8iuh – hTFIID + in RNA polymerase III pre-initiation complex - CryoEM
  • 7nvr, 7nvs, 7nvt, 7nvu – hTFIIA + TFIIB + TFIIE + TFIIF + in mediator with RNA polymerase II transcription pre-initiation complex - CryoEM
  • 5fyw – yTFIIA + yTFIIE + yTFIIF + DNA
  • 5fz5, 6gyl, 6gym – yTFIIA + yTFIIE + yTFIIF + DNA – Cryo EM
  • 6gyk – yTFIIA + yTFIIB + yTFIIF + DNA – Cryo EM
  • 5sva – yTFIIA + yTFIIB + yTFIIE + yTFIIF + DNA – Cryo EM
  • 4v1n, 4v1o – yTFIIB + yTFIIF – Cryo EM
  • 7ml0, 7ml2, 7ml4 - yTFIIB + TFIIE + TFIIF + in RNA polymerase II pre-initiation complex - CryoEM
  • 3k1f, 3k7a, 4bbr, 4bbs – yTFIIB in RNA polymerase complex
  • 7o72 – yTFIIB in RNA polymerase II transcription pre-initiation complex - CryoEM
  • 7o73 – yTFIIA + TFIIE + TFIIF + in RNA polymerase II transcription pre-initiation complex - CryoEM
  • 7o4i, 7o4j, 7o75 – yTFIIA + TFIIB + TFIIE + TFIIF + in RNA polymerase II transcription pre-initiation complex - CryoEM
  • 7zs9, 7zsa, 7zsb, 8bz1 – yTFIIA + TFIIB + TFIID + TFIIE + TFIIF + nucleosome in RNA polymerase II transcription pre-initiation complex - CryoEM
  • 5fmf, 5oqj, 5oqm – yTFIIA + yTFIIB + yTFIIE + yTFIIF + yTFIIH + DNA – Cryo EM
  • 6kf4, 6kf9 – TFIIF – Thermococcus kodakarensis - Cryo EM
• TF RRN or RNA polymerase I-specific transcription initiation factor RRN
  • 7oba – hTF RRN3 in RNA polymerase I – Cryo EM
  • 3tj1 – yTF RRN3
  • 5g5l – yTF RRN3 in RNA polymerase I
  • 6rqt, 6rrd – yTF RRN3 in RNA polymerase I – Cryo EM
  • 6ruo – yTF RRN3+RRN6+RRN11 in RNA polymerase I – Cryo EM
  • 5o7x – yTF RRN6+RRN7+RRN11
  • 5oa1, 5w5y, 5w64, 5w65, 5w66 – yTF RRN6+RRN7+RRN11 in RNA polymerase I – Cryo EM
  • 5n5y, 5n5z, 5n60, 5n61, 6rqh, 6rql, 6rui, 6rwe – yTF RRN3+RRN6+RRN7+RRN11 in RNA polymerase I – Cryo EM
  • 7z0o – yTF RRN5+RRN9+RRN10 in RNA polymerase I – Cryo EM
    

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Michal Harel, Openfox