TrkB tyrosine kinase receptor

spinqualitylabelsall models Human TrkB (yellow and pink) complex with neurotrophin-4/5 (cyan and green) and sulfate ions (PDB code 1hcf) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function TrkB tyrosine kinase receptor (TrkB) or BDNF/NT-3 growth factors receptor is part of the Trk tyrosine kinase receptors family which includes TrkA or (High affinity nerve growth factor receptor) and TrkC or NT-3 growth factor receptor which are responsible for mediating the trophic effects of the nerve growth factor family of neurotrophins. TrkB is activated by Brain-Derived Neurotrophic Factor (BDNF) and neurotrophin-4 (NT4). TrkB pathway is vital in neural development and maintenance through differentiation and neurogenesis. See also Neurotrophin Relevance Impairment of the BDNF-TrkB pathway is suspected to underlie the early dysfunction and prominent degeneration of striatal neurons in Huntington Disease. TrkB inhibitors are novel therapeutic drugs for inflammation-related depression. TrkB is a marker and mediator of carcinogenesis and metastasis. Its expression changes in neuroblastoma cells on exposure to various treatments. Structural highlights Structure of the TrkB-d5:NT-4/5 Complex, comprising one homodimer of NT-4/5 bound to two monomers of TrkB-d5. TrkB and neutrotrophin-4/5 interact via a specificity interaction site and via a conserved interaction site. 3D structures of TrkB tyrosine kinase receptor Updated on 20-August-2024 {"openlevels":0} TrkB Domains: ligand-binding 283-385; kinase 543-838 1wwb – hTrkB ligand-binding domain – human 1hcf – hTrkB ligand-binding domain + neurotrophin-4/5 5mo9 – hTrkB ligand-binding domain + antibody 4asz – hTrkB kinase domain 4at3, 4at4, 4at5 – hTrkB kinase domain + inhibitor TrkC NT-3 growth factor receptor 3v5q, 4ymj, 6kzc, 6kzd – hTrkC kinase domain + inhibitor 1wwc – hTrkC ligand-binding domain (mutant) 4pbv, 4pbw – TrkC + protein-tyrosine phosphatase - chicken

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