Tryptophan synthase 3D structures

3D structures of tryptophan synthase

Updated on 29-March-2026 - For a general description of the protein see Tryptophan synthase

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• Tryptophan synthase α subunit
  • 1rd5 - TrpS α subunit – corn
    
  • 3vnd - TrpS α subunit – Shewanella frigidimarina
    
  • 3tha - TrpS α subunit – Campylobacter jejuni
    
  • 3nav - TrpS α subunit – Vibrio cholerae
    
  • 1geq - PfTrpS α subunit - Pyrococcus furiosus
    
  • 2dzp, 2dzs, 2dzt, 2dzu, 2dzv, 2dzw, 2dzx, 2e09 - PfTrpS α subunit (mutant)
    
  • 1ujp - TtTrpS α subunit
    
  • 1v7y, 1wq5, 1xc4 - EcTrpS α subunit
    
  • 1xcf - EcTrpS α subunit (mutant)
    
  • 2ekc - TrpS α subunit – Aquifex aeolicus
    
  • 5kmy, 5k9x, 6oky - TrpS α subunit – Legionella pneumophila
    
  • 5n2p - SsTrpS α subunit – Sulfolobus solfataricus
    
  • 6oso, 6ouy - StTrpS α subunit – Salmonella typhimurium
    
  • 6qky - SpTrpS α subunit – Streptococcus pneumoniae
    
• Tryptophan synthase α binary complex
  • 1wxj - TtTrpS α subunit + indole propanol phosphate
    
• Tryptophan synthase β subunit
  • 1x1q - TtTrpS β subunit – Thermus thermophilus
    
  • 2dh6 - EcTrpS β subunit - Escherichia coli
    
  • 2o2e, 2o2j - MtTrpS β subunit – Mycobacterium tuberculosis
    
  • 1v8z, 5vm5, 6am7, 6am9, 6amc, 6amh, 6cuv - PfTrpS β1 subunit
    
  • 4neg - TrpS β subunit – Bacillus anthracis
    
• Tryptophan synthase β complex
  • 2dh5 - EcTrpS β subunit + PLP
    
  • 4qys, 6hte - SsTrpS β2 subunit + PLP
    
  • 5dvz - PfTrpS β1 subunit + PLP derivative
    
  • 6am7, 6amc, 6cuv, 7rnq - PfTrpS β1 subunit (mutant) + PLP derivative
    
  • 5dw0 - PfTrpS β1 subunit + Ser derivative
    
  • 5dw3 - PfTrpS β1 subunit + PLP derivative + Trp
    
  • 6am8, 6ami - PfTrpS β1 subunit (mutant) + PLP derivative + Trp
    
  • 5t6m - PfTrpS β1 subunit + PLP derivative + Trp derivative
    
  • 7rnp, 7rof - PfTrpS β1 subunit (mutant) + PLP derivative + Trp derivative
    
  • 6xsy - PfTrpS β1 subunit (mutant) + PLP derivative + inhibitor
    
  • 5vm5 - PfTrpS β1 subunit + PLP derivative + Ser derivative
    
  • 5ixj - PfTrpS β1 subunit + PLP derivative + Thr
    
  • 6am9, 6amh - PfTrpS β1 subunit (mutant) + PLP-Ser derivative
    
  • 6cut - PfTrpS β1 subunit (mutant) + Trp analog
    
  • 6cuz - PfTrpS β1 subunit (mutant) + PLP derivative + ethylserine
    
  • 8egy, 8egz - TmTrpS β1 subunit + PLP derivative – Thermotoga maritima
    
  • 8eh0 - TmTrpS β1 subunit + PLP derivative + quinoline derivative
    
• Tryptophan synthase α+β subunits
  • 1wdw - PfTrpS α + β subunits
    
  • 5tcf - MtTrpS α + β
    
  • 6wdu, 7a20, 7l5h, 7lev - StTrpS α + β
    
  • 7kq9 - StTrpS α + β (mutant)
    
  • 6v82 - TrpS α + β – Chlamydia trachomatis
    
• Tryptophan synthase α+β binary complex
  • 1ttp, 1ttq, 1bks, 2wsy, 1kfk, 7l4d, 7lx1, 8b03 - StTrpS α + β + PLP
    
  • 6dz4, 8b05, 8b08 - StTrpS α + β + PLP derivative
    
  • 1k7x, 2j9z, 7kmc, 7l47 - StTrpS α + β (mutant) + PLP
    
  • 3pr2, 4hn4, 4hpj, 4hpx, 4ht3, 4kkx, 7kwv, 7kxc, 7kyt, 7l03 - StTrpS α + β + inhibitor
    
  • 1kfj - StTrpS α + β + pyridoxal-serine-monophsphate
    
  • 1a5a, 1k8x - StTrpS α (mutant) + β + PLP
    
  • 1kfe - StTrpS α (mutant) + β + pyridoxal-serine-monophsphate
    
  • 7ku9, 7l1h, 7lgx, 7mt4, 7mt5, 7mt6 - StTrpS α + β + inhibitor
    
  • 6o1h, 6dzo, 6duc, 6d0v, 6c73, 6x0c, 7jmq, 7kbn, 7ki7 - StTrpS α + β (mutant) + inhibitor
    
  • 2j9y, 7lt4 - StTrpS α + β (mutant) + enoic acid derivative
    
  • 6xrh, 6xt0 - StTrpS α + β (mutant) + IGP + Ala derivative
    
  • 7jqw, 7k5a - StTrpS α + β (mutant) + Ser
    
  • 2tys - StTrpS α (mutant) + β (mutant) + Trp derivative
    
  • 5kzm - TrpS α + β + PLP derivative – Francisella tularensis
    
  • 5kin - SpTrpS α + β + PLP derivative – Streptococcus pneumoniae
    
  • 5e0k - PfTrpS α + β + PLP derivative
    
  • 5ocw, 5tcg, 5tci, 5tcj - MtTrpS α + β + inhibitor
    
  • 5tcf - MtTrpS α + β + PLP derivative
    
  • 5tch - MtTrpS α + β (mutant) + PLP derivative
    
  • 5e0k - PfTrpS α + β + PLP derivative
    
  • 5ey5 - TrpS α + β + PLP - synthetic
    
• Tryptophan synthase α+β ternary complex with PLP and inhibitor
  • 1a50, 1cw2, 1c9d, 1cx9, 1c8v, 1c29, 2cle, 2clh, 2cli, 2clk, 2cll, 2clm, 2clo, 2clf, 5bw6, 4zqc, 4y6g, 4xug, 4wx2, 5bw6, 6vnt, 6wx3, 6xin, 7kqf, 7lpf, 7lvx, 7ly8, 7m2l, 7m3s, 7me8 - StTrpS α + β + inhibitor + PLP
    
  • 1fuy, 7jhw, 7kh6 - StTrpS α + β (mutant) + inhibitor + PLP
    
  • 6xe3 - StTrpS α + β (mutant) + inhibitor + PLP derivative
    
• Tryptophan synthase α+β ternary complex with PLP and IGP derivatives
  • 1a5b, 1kfb - StTrpS α (mutant) + β + IGP + PLP
    
  • 1k8z - StTrpS α + β (mutant) + IGP derivative + PLP
    
  • 1kfc - StTrpS α (mutant) + β + IGP derivative + PLP
    
  • 1k3u, 1k7e, 1k7f - StTrpS α + β + IGP derivative + PLP
    
  • 1qoq, 2rh9, 2rhg - StTrpS α + β + IGP + PLP
    
  • 1qop - StTrpS α + β + IGP analog + PLP
    
  • 2trs, 1beu - StTrpS α (mutant) + β (mutant) + pyridoxal-serine-monophsphate + IGP analog
• Tryptophan synthase α+β ternary complex with PLP and G3P derivatives
  • 1wbj - StTrpS α + β + G3P + PLP
    
  • 2j9x - StTrpS α + β + G3P + acrylic acid derivative
    
  • 1k8y - StTrpS α + β (mutant) + G3P derivative + PLP
    
  • 1tjp - StTrpS α + β + G3P derivative + PLP
    
  • 2tsy - StTrpS α (mutant) + β (mutant) + pyridoxal-serine-monophsphate + G3P
• Other TrpS α+β ternary complex
  • 6hul - SsTrpS α + β subunits + PLP + Ser
    
  • 8b06 - StTrpS α + β + Ser + PLP
    
  • 7k0b - StTrpS α + β (mutant) + Ser + PLP
    
  • 1ubs - StTrpS α (mutant) + β (mutant) + Ser + PLP
    
  • 7jtt, 7ka1 - StTrpS α + β (mutant) + Ser + inhibitor
    
  • 6vfd - StTrpS α + β + quinoid derivative + Ser
    
  • 6xnc, 6xoy - StTrpS α + β + IGP + Trp derivative
    
  • 7lut - StTrpS α + β + PLP + Trp
    
  • 6usa - MtTrpS α + β + PLP derivative + piperazine derivative
    
• Tryptophan synthase α+β quaternary complex
  • 1a5s - StTrpS α + β + Ser + inhibitor + PLP
    
  • 5cgq, 7lkl, 7ltp - StTrpS α + β + Trp + inhibitor + PLP
    
  • 7lv5 - StTrpS α + β + His + inhibitor + PLP
    
  • 7jll - StTrpS α + β (mutant) + Trp + inhibitor + PLP
    
  • 3cep - StTrpS α + β + G3P + indoline + PLP
    
  • 6uap, 6ub9, 6dwe, 6e9p - MtTrpS α + β + malonate + inhibitor + PLP derivative
    
  • 6u6c - MtTrpS α + β + PLP derivative + sulfonamide derivative + Ala
    
• Dimethylallyl tryptophan synthase or tryptophan 6-prenyltransferase
  • 3i4z - AfDATrpS – Aspergillus fumigatus
    
  • 3i4x - AfDATrpS + DMAPP + Trp
    
  • 4ld7 - DATrpS + thiopyrophosphate – Neosartoria fischeri<br />
  • 6zs0 - ScDATrpS – Stretptomyces coelicolor
    
  • 5inj, 6zrz, 7w8v, 7w8w, 7w8x - ScDATrpS + DMASPP + Trp
    
  • 7y8y - ScDATrpS + thiopyrophosphate + DMASPP + Trp
    
  • 6zry - MoDATrpS + Trp – Micromonospora olivasterospora
    
  • 6zrx - MoDATrpS + DMAPP + Trp
    

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