Tumor necrosis factor receptor

spinqualitylabelsall models Structure of human TNFR extracellular domain complex with sulfate and Mg+2 ion (green) (PDB code 1ext). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Tumor necrosis factor receptor (TNFR) or death receptor is a trimeric cytokine receptor which binds TNF. TNFR family contains several members and superfamily (TNFRSF) members. TNFRSF 1 is called Lymphotoxin-α or TNF-β; TNFRSF 3 is called TNFR-III; TNFRSF 4 is called OX40L receptor; TNFRSF 5 is called CD40L receptor; TNFRSF 6 is called Fas; TNFRSF 9 is called 4-1BBL; TNFRSF 10 see TRAIL; TNFRSF 10B is called Dr5; TNFRSF 11A is called RANK; TNFRSF 11B is called Osteoprotegerin; TNFRSF 12 is called TWEAK; TNFRSF 12A is called TWEAKR; TNFRSF 13B is called BAFF or sTALL-1; TNFRSF 13C is called BAFF receptor; TNFRSF 14 is called LIGHT; TNFRSF 16 is called Low-affinity nerve growth factor receptor; p75NTR; p75 neurotrophin receptor; TNFRSF 18 is called GITRL; TNFRSF 21 is called Dr6; TNFRSF 25 is called Dr3; See also Tumor necrosis factor ligand superfamily Cytokine receptors Receptor Immune receptors Relevance TRAPS - a condition characterized by recurrent episodes of fever is associated with TNFR. Structural highlights The extracellular domain of TNFR contains 2 to 6 cysteine-rich domains (CRD). The CRD domains are ca. 40 amino-acid long and contain 4-6 cysteine residues. The CRDs are involved in binding of TNF. Mg coordination site. Water molecules are shown as red spheres. 3D structures of tumor necrosis factor receptor Tumor necrosis factor receptor 3D structures

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Michal Harel, Alexander Berchansky