UDP-N-acetylglucosamine acyltransferase

spinqualitylabelsall models E. coli UDP-N-acetylglucosamine acyltransferase complex with UDP-Glc-NAC (PDB code 2jf3) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function UDP-N-acetylglucosamine acyltransferase or Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (LpxA) initiates lipid A biosynthesis. It catalyzes the transfer of 3-hydroxymyristic acid from acyl carrier protein to the 3'-hydroxyl group of UDP-GlcNAc. Structural highlights The substrate-binding site of LpxA interacts with the substrate UDP moiety and the Glc-NAc moiety. It contains a His-Asp catalytic dyad where the His acts as a general base and Asp helps to orient the His for participation in the catalysis. 3D structures of UDP-N-acetylglucosamine acyltransferase UDP-N-acetylglucosamine acyltransferase 3D structures

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman