Uridylate kinase

spinqualitylabelsall models Uridylate kinase hexamer complex with ligand UMP, Cd+ (gold) and Mg+2 (green) ions 2j4k Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Uridylate kinase (UK) catalyzes the reversible transfer of phosphate from UMP to UDP using ATP as a phosphate source. UDP is the starting point of synthesis of all other pyrimidine nucleotides. The eukaryotic UK has specificity to both UMP and CMP while the bacterial one is specific for UMP. The bacterial UK is Mg+2 dependent and is activated by GTP and repressed by UTP. The bacterial UK is composed of a C terminal ATP-binding domain and an N terminal UMP-binding domain. Structural highlights The biological assembly of Uridylate kinase from Sulfolobus solfataricus (2j4k) is homohexamer. The active site of UK has high specificity to uracil and excludes purine nucleotides. Water molecule is shown as red sphere.

3D structures of uridylate kinase

Updated on 21-June-2022

{"openlevels":0}

• Uridylate kinase
  • 2j4k – UK – Neisseria meningitides
    
  • 1z9d – UK – Streptococcus pyogenes
    
  • 2a1f - UK - Haemophilus influenza
    
  • 2brx – PfUK – Pyrococcus furiosus
    
  • 2ij9 – UK (mutant) – Archaeoglobus fulgidus
    
  • 2va1 - UK – Ureaplasma parvum
    
  • 3ek6 – XcUK – Xanthomonas campestris
• Uridylate kinase complex with nucleotides
  • 1uky – yUK + ADP – yeast
    
  • 1ukz – yUK + AMP + ADP
    
  • 2bne – EcUK (mutant) + UMP – Escherichia coli
    
  • 2bnd - EcUK (mutant) + UDP
    
  • 2bnf - EcUK (mutant) + UTP
    
  • 2v4y - EcUK (mutant) + GTP
    
  • 2bmu - PfUK + UMP + AMPPNP
    
  • 2bri - PfUK + AMPPNP
    
  • 2ji5 - PfUK (mutant) + UTP
    
  • 2j4j - SsUK + UMP + AMPPCP – Sulfolobus solfataricus
    
  • 2j4k - SsUK + UMP
    
  • 2j4l - SsUK + UTP
    
  • 2jjx - UK + ATP + Mg – Bacillus anthracis
    
  • 3ek5 - XcUK + GTP
    
  • 3nwy – MtUK + UTP + GTP – Mycobacterium tuberculosis
    
  • 7bex, 7bix, 7bl7 - MtUK + UTP + UDP
    
  • 4a7x, 4a7w - UK + UDP – Helicobacter pylori
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky