The initial view shows proteins in white and the three snRNAs in colour (U4: orange, U5: red, and U6: purple). Focusing on the RNAs reveals secondary structure and extensive base pairing between the U4 and U6 snRNAs. The spliceosome is assembled from the U4/U6.U5 tri-snRNP, the U1 snRNP, and the U2 snRNP. The U2 snRNP interacts with the region highlighted in blue in this view. The U1 snRNP interacts with the U2 snRNP. The initial assembly is inactive; extensive conformational changes (including unwinding of the U4/U6 base pairing) are required for activation of the spliceosome. For the source article see Nguyen et al, 2016[1].
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This page was last modified 16:21, 18 March 2016.