Amylin Receptor, AMYr, Protein

Introduction

Amylin Receptor

^[1]

Function

TextToBeDisplayed Overlay of RAMPs Overlay of Ligands Arg 180 and Gln 390 interaction Hydrophobic interactions in G protein activation

Disease

File:Bio role.jpg

Figure number

Relevance

^[2] ^[3] ^[4] ^[5]

^[6]

^[7]

DOI:10.1016/j.mad.2018.03.010

Structural highlights

Transmembrane TextToBeDisplayed

↑ Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM. A structural basis for amylin receptor phenotype. Science. 2022 Mar 25;375(6587):eabm9609. PMID:35324283 doi:10.1126/science.abm9609
↑ Hay DL, Chen S, Lutz TA, Parkes DG, Roth JD. Amylin: Pharmacology, Physiology, and Clinical Potential. Pharmacol Rev. 2015 Jul;67(3):564-600. PMID:26071095 doi:10.1124/pr.115.010629
↑ Grizzanti J, Corrigan R, Casadesus G. Neuroprotective Effects of Amylin Analogues on Alzheimer's Disease Pathogenesis and Cognition. J Alzheimers Dis. 2018;66(1):11-23. PMID:30282360 doi:10.3233/JAD-180433
↑ Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM. A structural basis for amylin receptor phenotype. Science. 2022 Mar 25;375(6587):eabm9609. PMID:35324283 doi:10.1126/science.abm9609
↑ Mathiesen DS, Lund A, Vilsbøll T, Knop FK, Bagger JI. Amylin and Calcitonin: Potential Therapeutic Strategies to Reduce Body Weight and Liver Fat. Front Endocrinol (Lausanne). 2021 Jan 8;11:617400. PMID:33488526 doi:10.3389/fendo.2020.617400
↑ Thapa, G., Kumari, A., Dasgupta, D., Bandyopadhy, S., Sarkar, N., Roy, K., Karunakaran, G., Kazmi, I., Karmakar, S., & Chakraborty, M. (2023). Chapter 5- Insight into the mechanism of action of anti-diabetic drugs. How Synthetic Drugs Work. 95-122. DOI:10.1016/B978-0-323-99855-0.00005-1
↑ Press, M., Jung, T., Konig, J., Grune, T., & Hohn, A. (2019). Protein aggregates and proteostasis in aging: Amylin and β-cell function. Mechanisms of Ageing and Development. 3, 46-54. DOI:10.1016/j.mad.2018.03.010

References

^[1] <ref name="Hay"> <ref name="Grizzanti"> <ref name="Cao"> <ref name="Mathiesen"> <ref name="Thapa"> <ref name="Press">

Student Contributors

Kylie Blake
Natalie Link
Jaelin Lunato

↑ Cite error: Invalid <ref> tag; no text was provided for refs named 7TYF

Proteopedia Page Contributors and Editors (what is this?)

Kylie Blake

[7TYF-1] Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM. A structural basis for amylin receptor phenotype. Science. 2022 Mar 25;375(6587):eabm9609. PMID:35324283 doi:10.1126/science.abm9609

[Hay-2] Hay DL, Chen S, Lutz TA, Parkes DG, Roth JD. Amylin: Pharmacology, Physiology, and Clinical Potential. Pharmacol Rev. 2015 Jul;67(3):564-600. PMID:26071095 doi:10.1124/pr.115.010629

[Grizzanti-3] Grizzanti J, Corrigan R, Casadesus G. Neuroprotective Effects of Amylin Analogues on Alzheimer's Disease Pathogenesis and Cognition. J Alzheimers Dis. 2018;66(1):11-23. PMID:30282360 doi:10.3233/JAD-180433

[Cao-4] Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM. A structural basis for amylin receptor phenotype. Science. 2022 Mar 25;375(6587):eabm9609. PMID:35324283 doi:10.1126/science.abm9609

[Mathiesen-5] Mathiesen DS, Lund A, Vilsbøll T, Knop FK, Bagger JI. Amylin and Calcitonin: Potential Therapeutic Strategies to Reduce Body Weight and Liver Fat. Front Endocrinol (Lausanne). 2021 Jan 8;11:617400. PMID:33488526 doi:10.3389/fendo.2020.617400

[Thapa-6] Thapa, G., Kumari, A., Dasgupta, D., Bandyopadhy, S., Sarkar, N., Roy, K., Karunakaran, G., Kazmi, I., Karmakar, S., & Chakraborty, M. (2023). Chapter 5- Insight into the mechanism of action of anti-diabetic drugs. How Synthetic Drugs Work. 95-122. DOI:10.1016/B978-0-323-99855-0.00005-1

[Press-7] Press, M., Jung, T., Konig, J., Grune, T., & Hohn, A. (2019). Protein aggregates and proteostasis in aging: Amylin and β-cell function. Mechanisms of Ageing and Development. 3, 46-54. DOI:10.1016/j.mad.2018.03.010

[7TYF-1] Cite error: Invalid <ref> tag; no text was provided for refs named 7TYF

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Amylin Receptor, AMYr, Protein

Contents

Introduction

Function

Disease

Relevance

Structural highlights

References

Student Contributors

Proteopedia Page Contributors and Editors (what is this?)

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