User:Michael Strong/TB

Web Supplement to:
Comprehensive Structural Analysis of Drug-Resistant Mutations in Mycobacterium tuberculosis.

Michael Strong ^1,2, Andreas Sandgren ^3,4, James E. Galagan ^5,6, Mark Borowsky ^5,7,8, George M. Church ², Megan B. Murray ³,

1.Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, 80206,
2.Department of Genetics, Harvard Medical School, Boston, MA 02115,
3.Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115,
4.European Centre for Disease Prevention and Control,
5.Broad Institute of MIT and Harvard, Cambridge, MA, 02142,
6.College of Engineering, Boston University, Boston, MA, 02118,
7.Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, 02114,
8.Department of Genetics, Massachusetts General Hospital, Boston, MA, 02114.

Correspondence regarding this webpage can be sent to: StrongM@NJHealth.org

Please click on the GREEN links to see the structural details described.

RpoB homology model with Rifampin bound

spinqualitylabelsall models RpoB Homology Model with Rifampin bound Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D

RpoB homology model with rifampin bound

RpoB homology model with resistance mutations

RpoB rifampin binding site

Rifampin

GidB homology model with S-adenosylmethionine bound

spinqualitylabelsall models GidB homology model with S-adenosylmethionine bound Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D

GidB homology model with S-adenosylmethionine bound

GidB homology model with resistance mutations

GidB S-adenosylmethionine binding site

GidB homology model with resistance mutations (Space Fill Representation)

S-adenosylmethionine

RpsL homology model with streptomycin

spinqualitylabelsall models RpsL homology model with streptomycin Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D

RpsL homology model with streptomycin

RpsL homology model with resistance mutations

RpsL homology model interaction with streptomycin (positioning derived from the Thermus thermophilus 30S ribosomal subunit in complex with streptomycin

Streptomycin

InhA crystal structure with ETH-NAD bound

spinqualitylabelsall models InhA with ETH-NAD, X-ray Crystal Structure 2h9i Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D

InhA with ETH-NAD with drug resistance mutations

Resistance Mutations Ser94Ala, Ile95Pro

ETH-NAD

InhA crystal structure with INH-NAD bound

spinqualitylabelsall models InhA with INH-NAD, X-ray Crystal Structure 2nv6 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D

InhA with INH-NAD with drug resistance mutations in red

Resistance Mutations Ile16Thr, Ile21Val, Ile47Thr, Val78Ala, Ser94Ala, Ser94Leu, Ile95Pro, Ile95Thr, Ile194Thr

INH-NAD

GyrA crystal structure

spinqualitylabelsall models GyrA X-ray Crystal Structure 3ILW Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D

GyrA homodimer

GyrA homodimer with resistance mutations

GyrA homodimer quinolone binding and resistance region

KatG crystal structure with heme bound

spinqualitylabelsall models KatG, X-ray Crystal Structure 2cca Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D

KatG dimer with bound heme molecules

KatG with Isoniazid Resistance Mutations in Red

KatG S315 near the heme

PncA crystal structure

spinqualitylabelsall models PncA, X-ray Crystal Structure 3GBC Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D

PncA crystal structure with resistance mutations

PncA crystal structure with resistance mutations and catalytic cysteine

PncA crystal structure with mutations and catalytic cysteine indicated (Space Fill Representation)

Proteopedia Page Contributors and Editors (what is this?)

Michael Strong