User:Tilman Schirmer/Sandbox 60

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Bacterial potassium channel

1k4c

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KcsA bacterial potassium channel in complex with monoclonal Fab fragments 1k4c.

View down the channel axis on the molecular 4-fold symmetry axis with modeled K+ ions in magenta.

The ions are coordinated by main-chain carbonyl groups (only one subunit shown).

The ion in the hydrophobic cavity is coordinated by 8 water molecules.


Reference

  1. Zhou Y, Morais-Cabral JH, Kaufman A, MacKinnon R. Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution. Nature. 2001 Nov 1;414(6859):43-8. PMID:11689936 doi:https://dx.doi.org/10.1038/35102009

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Tilman Schirmer

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