Vinculin
Vinculin (VCL) is involved in adhesion by linking integrin molecules to the actin cytoskeleton. Its head domain (Vd1) can bind to talin or to alpha-actinin at their respective VCL Binding Sites (VBS). A splice variant of vinculin is meta-vinculin (m-VCL). The protein raver1 RNA Recognition Motif (RRM) forms a complex with VCL or m-VCL.
Updated on 19-March-2024
{"openlevels":0}
- Vinculin; Domains - head 140-327; tail 878-1066
- 1tr2, 6fuy – hVCL - human
- 3h2u – hVCL head domain + raver1 RRM
- 2ibf, 2hsq, 2gww - hVCL head domain + SfVCL binding sites from Shigella flexneri
- 1ydi - hVCL head domain +hActinin VBS
- 1syq, 1rkc, 1rke – hVCL head domain +hTalin VBS
- 1qkr – hVCL tail domain
- 3h2v - hVCL tail domain + raver1 RRM
- 4pr9 - hVCL tail domain + lipid
- 3jbi - hVCL tail domain + actin – Cryo-EM
- 6nr7 - cVCL – chicken
- 1t01 - cVCL head domain +mTalin VBS
- 3zdl – cVCL head domain + amyloid β precursor protein N terminal
- Metavinculin; Domains - head 1-256; tail 959-1134
- 7ktt, 7ktu, 7ktv, 7ktw – hVCL – Cryo-EM
- 6upw – hVCL + actin + ADP – Cryo-EM
- 6fuy - hVCL
- 3rf3 - hVCL head domain + invasin IPAA
- 3s90 - hVCL head domain + mTalin-1 peptide
- 4dj9 - hVCL head domain + hTalin-1 peptide
- 6fq4 - hVCL head domain + TARP peptide
- 3tj5 - hVCL head domain + Sca-family protein peptide
- 3tj6 - hVCL head domain + protein Ps 120 peptide
- 4ehp, 5y04 - hVCL head domain + catenin α-1 residues 277-382
- 3myi – hVCL tail domain
- 5l0f, 5l0i, 5l0j - hVCL tail domain (mutant)
- 5l0c, 5l0d - hVCL tail domain + lipid
- 5l0g, 5l0h - hVCL tail domain (mutant) + lipid
- 3jbk – hVCL tail domain + actin – Cryo-EM
- 6upw - mVCL head domain + catenin α-1
- 3vf0 – hVCL tail domain + ribonucleoprotein PTB-binding
- 1st6 – cVCL
- 2gdc – cVCL head domain +SfInvasin C-terminal
- 1xwj - cVCL head domain +cTalin VBS3
- 1zvz, 1zw2, 1zw3, 1u6h - cVCL head domain +cTalin rod
- 6fq4 – cVCL head domain + TARP-VBS1
- 4e17, 4e18 - cVCL head domain + catenin α-1 VCL-binding domain
Vinculin
Vinculin (VCL) is involved in adhesion by linking integrin molecules to the actin cytoskeleton. Its head domain (Vd1) can bind to talin or to alpha-actinin at their respective VCL Binding Sites (VBS). A splice variant of vinculin is meta-vinculin (m-VCL). The protein raver1 RNA Recognition Motif (RRM) forms a complex with VCL or m-VCL.
Updated on 19-March-2024
{"openlevels":0}
- Vinculin; Domains - head 140-327; tail 878-1066
- 1tr2, 6fuy – hVCL - human
- 3h2u – hVCL head domain + raver1 RRM
- 2ibf, 2hsq, 2gww - hVCL head domain + SfVCL binding sites from Shigella flexneri
- 1ydi - hVCL head domain +hActinin VBS
- 1syq, 1rkc, 1rke – hVCL head domain +hTalin VBS
- 1qkr – hVCL tail domain
- 3h2v - hVCL tail domain + raver1 RRM
- 4pr9 - hVCL tail domain + lipid
- 3jbi - hVCL tail domain + actin – Cryo-EM
- 6nr7 - cVCL – chicken
- 1t01 - cVCL head domain +mTalin VBS
- 3zdl – cVCL head domain + amyloid β precursor protein N terminal
- Metavinculin; Domains - head 1-256; tail 959-1134
- 7ktt, 7ktu, 7ktv, 7ktw – hVCL – Cryo-EM
- 6upw – hVCL + actin + ADP – Cryo-EM
- 6fuy - hVCL
- 3rf3 - hVCL head domain + invasin IPAA
- 3s90 - hVCL head domain + mTalin-1 peptide
- 4dj9 - hVCL head domain + hTalin-1 peptide
- 6fq4 - hVCL head domain + TARP peptide
- 3tj5 - hVCL head domain + Sca-family protein peptide
- 3tj6 - hVCL head domain + protein Ps 120 peptide
- 4ehp, 5y04 - hVCL head domain + catenin α-1 residues 277-382
- 3myi – hVCL tail domain
- 5l0f, 5l0i, 5l0j - hVCL tail domain (mutant)
- 5l0c, 5l0d - hVCL tail domain + lipid
- 5l0g, 5l0h - hVCL tail domain (mutant) + lipid
- 3jbk – hVCL tail domain + actin – Cryo-EM
- 6upw - mVCL head domain + catenin α-1
- 3vf0 – hVCL tail domain + ribonucleoprotein PTB-binding
- 1st6 – cVCL
- 2gdc – cVCL head domain +SfInvasin C-terminal
- 1xwj - cVCL head domain +cTalin VBS3
- 1zvz, 1zw2, 1zw3, 1u6h - cVCL head domain +cTalin rod
- 6fq4 – cVCL head domain + TARP-VBS1
- 4e17, 4e18 - cVCL head domain + catenin α-1 VCL-binding domain
