Focal adhesion kinase

spinqualitylabelsall models Focal adhesion kinase 1 kinase domain complex with pyrimidine derivative inhibitor and sulfate (PDB code 2jkk) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Focal adhesion kinase (FAK) is involved in cellular adhesion. During apoptosis, FAK is cleaved into 2 fragments. The smaller fragment is associated with death signaling. For details on focal adhesion kinase or protein tyrosine kinase 2β (PTK2) see Molecular Playground/FAK. Relevance FAK is overexpressed in many tumor cells. Hence they are investigated as anti-tumor drug targets. Structural insights FAK ATP-binding site is the location of inhibitor binding. 3D Structures of focal adhesion kinase Focal adhesion kinase 3D structures

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