Metabotropic glutamate receptor

spinqualitylabelsall models Structure of the glycosylated rat binding domain of the Metabotropic Glutamate Receptor, GluR1, bound to glutamate, Hepes and Mg+2 ions (1ewk) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Metabotropic glutamate receptors are glutamate receptors that activate ion channels indirectly through a signaling cascade involving G proteins. They are members of the large class of seven-transmembrane domain receptors, the G protein-coupled receptors. Glutamate receptors are classified into 3 groups based on their homology, mechanism and pharmacological properties. See also Ligand Binding N-Terminal of Metabotropic Glutamate Receptors. Metabotropic glutamate receptor 1 and metabotropic glutamate receptor 5 belong to group I and activate phospholipase C. For details see Metabotropic glutamate receptor 5. Metabotropic glutamate receptor 2 and metabotropic glutamate receptor 3 belong to group II and inhibit the cyclic AMP cascade. Metabotropic glutamate receptor 7 and metabotropic glutamate receptor 8 belong to group III and inhibits adenylate cyclase activity. Articles in Proteopedia concerning Toll-like Receptors include: Leucine-rich repeat Membrane proteins Relevance GluR are targets for Parkinson's disease drugs as well as for Alzheimer's disease, depression, anxiety and schizophrenia. Structural highlights Glutamate is bound to GluR1 in the crevice between the N-terminal and C-terminal domains. Water molecules are shown as red spheres. 3D structures of metabotropic glutamate receptor Metabotropic glutamate receptor 3D structures

See Also

glutamate receptors
G protein-coupled receptors
Ligand Binding N-Terminal of Metabotropic Glutamate Receptors

• Metabotropic glutamate receptor 5
• Leucine-rich repeat
• Membrane proteins

Proteopedia Page Contributors and Editors (what is this?)

Wayne Decatur, Michal Harel, Alexander Berchansky, Nikki Hunter