Metabotropic glutamate receptor 3D structures

3D structures of metabotropic glutamate receptor

Updated on 18-December-2025

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• Metabotropic glutamate receptor 1; Domains – LBD 1-564; transmembrane 569-836
  • 7dgd – hMGluR1 - human – Cryo EM
    
  • 7dge – hMGluR1 + nanobody + quisqualate – Cryo EM
    
  • 3ks9 – hMGluR1 (mutant) + antagonist
  • 4or2 - hMGluR1/cytochrome b526
    
  • 1ewt, 1ewv - rMGluR1 LBD - rat
  • 1isr, 1ewk – rMGluR1 LBD + Glu
  • 1iss - rMGluR1 LBD + antagonist
• Metabotropic glutamate receptor 2
  • 7epa – hMGluR2 – Cryo EM
    
  • 7epd – hMGluR2/GluR7 – Cryo EM
    
  • 7epb – hMGluR2 (mutant) + nanobody – Cryo EM
    
  • 7mtq – hMGluR2 + antagonist – Cryo EM
    
  • 7mtr – hMGluR2 + antagonist + Glu – Cryo EM
    
  • 7mts – hMGluR2 in Gi complex + Glu – Cryo EM
    
  • 7e9g – hMGluR2 (mutant) in Gi complex + antagonist + scFv – Cryo EM
    
  • 4xaq, 4xas – hMGluR2 LBD + agonist
    
  • 5kzn, 5kzq – hMGluR2 LBD + antagonist
    
  • 5cni – hMGluR2 LBD + Glu
    
  • 5cnj – hMGluR2 LBD + Glu analog
    
  • 7epe, 7epf – hMGluR2 transmembrane domain + antagonist + FMN
    
• Metabotropic glutamate receptor 3
  • 7wi6, 7wi8, 7wih – hMGluR3 – Cryo EM
    
  • 5cnk – hMGluR3 LBD + Glu
    
  • 3sm9 - hMGluR3 + antagonist
  • 8tqb – hMGluR3 + agonist – Cryo EM
    
  • 9ii2, 9ii3 – hMGluR3 + beta-arrestin – Cryo EM
    
  • 4xar, 6b7h – hMGluR3 LBD + agonist
    
  • 5cnm – hMGluR3 LBD + Glu analog
    
  • 2e4u – rMGluR3 LBD (mutant) + Glu
  • 8tr2 – rMGluR3 + agonist – Cryo EM
    
  • 8tr0, 8trd – rMGluR3 + antagonist – Cryo EM
    
  • 8trc – rMGluR3 + antagonist + modulator – Cryo EM
    
  • 2e4v, 2e4w, 2e4x, 2e4y, 2e4z - rMGluR3 LBD (mutant) + agonist
• Metabotropic glutamate receptor 4
  • 8jd6 – hMGluR4 in Gi complex – Cryo EM
    
  • 7e9h – hMGluR4 in Gi complex + antagonist + scFv – Cryo EM
    
• Metabotropic glutamate receptor 5
  • 6n52 – hMGluR5 – Cryo EM
    
  • 7fd9 – hMGluR5 + antagonist – Cryo EM
    
  • 7fd8, 8x0b, 8x0c, 8x0d, 8x0e, 8x0f, 8x0g, 8x0h – hMGluR5 + quisqualate – Cryo EM
    
  • 8t7h, 8t8m, 8tao – hMGluR5 + nanobody + quisqualate – Cryo EM
    
  • 6n4y, 6n50, 6n51, 6njc – hMGluR5 + nanobody + quisqualate – Cryo EM
    
  • 8t6j – hMGluR5 + activator – Cryo EM
    
  • 6n4x – hMGluR5 LBD
    
  • 3lmk – hMGluR5 LBD (mutant) + positive allosteric modulator + Glu
  • 6ffh, 6ffi - hMGluR5 LBD (mutant) + positive allosteric modulator
    
  • 9hc3 - hMGluR5 transmembrane domain/endolysin
    
  • 9hc0 - hMGluR5 transmembrane domain/endolysin + alloswitchc
    
  • 4oo9, 5cgc, 5cgd - hMGluR5 transmembrane domain + negative allosteric modulator
    
  • 7p2l - hMGluR5 transmembrane domain (mutant) + negative allosteric modulator
    
• Metabotropic glutamate receptor 7
  • 7epc, 9omo, 9omp – hMGluR7 – Cryo EM
    
  • 5c5c – hMGluR7 LBD (mutant)
    
  • 3mq4 – hMGluR7 LBD + antagonist
• Metabotropic glutamate receptor 8
  • 9mbd – hMGluR8 – Cryo EM
    
  • 9mbb – hMGluR8 + antagonist – Cryo EM
    
  • 9mbc – hMGluR8 + agonist – Cryo EM
    
  • 9mb9 – hMGluR8 + guanine nucleotide-binding protein G – Cryo EM
    
  • 9mba – hMGluR8 + arrestin-1 + scFv – Cryo EM
    
  • 6bsz – hMGluR8 LBD + Glu
    
  • 6bt5 – hMGluR8 LBD + phosphonobutanoic acid
    
  • 6e5v – hMGluR8 N-terminal (mutant) + inhibitor
    
• Metabotropic glutamate receptor 2+3
  • 8jcu, 8jcv, 8jcw, 8jcx, 8jcy, 8jcz, 8jd0, 8jd1, 8jd2 – hMGluR + Glu – Cryo EM
    
  • 8jd3 – hMGluR in GI complex – Cryo EM
    
• Metabotropic glutamate receptor 2+4
  • 8jd4, 8wgd – hMGluR – Cryo EM
    
  • 8jd5, 8wgb – hMGluR in GI complex – Cryo EM
    
  • 8wg9, 8wgc – hMGluR + agonist – Cryo EM
    

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Michal Harel