View source for 12ad


==Structure of mammalian Type 2 Inositol 1,4,5-trisphosphate receptors (IP3R2) in the Apo-state==
<StructureSection load='12ad' size='340' side='right'caption='[[12ad]], [[Resolution|resolution]] 3.32&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[12ad]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=12AD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=12AD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.32&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLX:(9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL'>PLX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=12ad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=12ad OCA], [https://pdbe.org/12ad PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=12ad RCSB], [https://www.ebi.ac.uk/pdbsum/12ad PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=12ad ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ITPR2_MOUSE ITPR2_MOUSE] Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm (PubMed:15632133, PubMed:19608738, PubMed:20189985, PubMed:22547632, PubMed:25329695). Exists in two states; a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity (PubMed:22547632).<ref>PMID:15632133</ref> <ref>PMID:19608738</ref> <ref>PMID:20189985</ref> <ref>PMID:22547632</ref> <ref>PMID:25329695</ref>   Has neither inositol 1,4,5-trisphosphate binding activity nor calcium releasing activity.<ref>PMID:15632133</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Baker MR]]
[[Category: Fan G]]
[[Category: Serysheva II]]