View source for 1gwc


==The structure of a tau class glutathione S-transferase from wheat, active in herbicide detoxification==
<StructureSection load='1gwc' size='340' side='right'caption='[[1gwc]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1gwc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Aegilops_tauschii Aegilops tauschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GWC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTX:S-HEXYLGLUTATHIONE'>GTX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gwc OCA], [https://pdbe.org/1gwc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gwc RCSB], [https://www.ebi.ac.uk/pdbsum/1gwc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gwc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/O04941_AEGTA O04941_AEGTA] 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gw/1gwc_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gwc ConSurf].
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== Publication Abstract from PubMed ==
Glutathione S-transferases (GSTs) from the phi (GSTF) and tau (GSTU) classes are unique to plants and play important roles in stress tolerance and secondary metabolism as well as catalyzing the detoxification of herbicides in crops and weeds. We have cloned and functionally characterized a group of GSTUs from wheat treated with fenchlorazole-ethyl, a herbicide safener. One of these enzymes, TaGSTU4-4, was highly active in conjugating the chemically distinct wheat herbicides fenoxaprop and dimethenamid. The structure of TaGSTU4-4 has been determined at 2.2 A resolution in complex with S-hexylglutathione. This enzyme is the first tau class GST structure to be determined and most closely resembles the omega class GSTs, but without the unique N-terminal extension or active site cysteine. The X-ray structure identifies key amino acid residues in the hydrophobic binding site and provides insights into the substrate specificity of these enzymes.

Structure of a tau class glutathione S-transferase from wheat active in herbicide detoxification.,Thom R, Cummins I, Dixon DP, Edwards R, Cole DJ, Lapthorn AJ Biochemistry. 2002 Jun 4;41(22):7008-20. PMID:12033934<ref>PMID:12033934</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1gwc" style="background-color:#fffaf0;"></div>

==See Also==
*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Aegilops tauschii]]
[[Category: Large Structures]]
[[Category: Cole DJ]]
[[Category: Cummins I]]
[[Category: Dixon DP]]
[[Category: Edwards R]]
[[Category: Lapthorn AJ]]
[[Category: Thom R]]