View source for 1jgk


==SOLUTION STRUCTURE OF CANDOXIN==
<StructureSection load='1jgk' size='340' side='right'caption='[[1jgk]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1jgk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bungarus_candidus Bungarus candidus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JGK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JGK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 19 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jgk OCA], [https://pdbe.org/1jgk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jgk RCSB], [https://www.ebi.ac.uk/pdbsum/1jgk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jgk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/3NO4_BUNCA 3NO4_BUNCA] Binds and inhibits muscular and neuronal nicotinic acetylcholine receptors (nAChR). Is a reversible antagonist of muscle nAChR (alpha-1-beta-1-delta-epsilon/CHRNA1-CHRNB1-CHRND-CHRNE) (IC(50)=10 nM) and a potent and poorly reversible antagonist of the neuronal alpha-7/CHRNA7 nAChR (IC(50)=50 nM). May exhibit differential affinities for the two binding sites on the muscle nAChR.<ref>PMID:11884390</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jg/1jgk_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jgk ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bungarus candidus]]
[[Category: Large Structures]]
[[Category: Chary KVR]]
[[Category: Govil G]]
[[Category: Kini MR]]
[[Category: Venkitakrishnan RP]]