View source for 1sjw


==Structure of polyketide cyclase SnoaL==
<StructureSection load='1sjw' size='340' side='right'caption='[[1sjw]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1sjw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_nogalater Streptomyces nogalater]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SJW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SJW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NGV:METHYL+5,7-DIHYDROXY-2-METHYL-4,6,11-TRIOXO-3,4,6,11-TETRAHYDROTETRACENE-1-CARBOXYLATE'>NGV</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sjw OCA], [https://pdbe.org/1sjw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sjw RCSB], [https://www.ebi.ac.uk/pdbsum/1sjw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sjw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SNOAL_STRNO SNOAL_STRNO] Involved in the biosynthesis of the aromatic polyketide antibiotic nogalamycin. Catalyzes the formation of nogalaviketone from nogalonic acid methyl ester (NAME), the last ring-closure step in the biosynthesis of nogalamycin.<ref>PMID:10639368</ref> <ref>PMID:15071504</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sj/1sjw_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sjw ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Streptomyces nogalater]]
[[Category: Jansson A]]
[[Category: Kallio P]]
[[Category: Mantsala P]]
[[Category: Neimi J]]
[[Category: Schneider G]]
[[Category: Sultana A]]
[[Category: Wang JS]]